Registry update — unassessed
Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise
Trial registry update: RECRUITING. No results reported in the supplied registry record.
OBSERVATIONALN=120Minor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 18, 2026 · Discovered: Sep 18, 2026 · Assessed: — · Research update
What it does not prove
- This is a study protocol describing planned methods, not a report of completed results—no findings about the actual effects of resistance training are presented
- The absence of a control group means the design cannot establish whether observed changes result from the intervention or other factors
- Mechanistic assessments (mitochondrial function, transcriptomics) are proposed but cannot validate whether changes in these cellular markers causally link to clinical improvements in frailty or physical function
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Observational
- Sample size
- 120
- Duration
- 2 months
- Population
- approximately 120 participants comprising older adults with type 2 diabetes mellitus, healthy older adults, and young healthy controls
- Primary outcome
- improvement in skeletal muscle health and physical function following resistance training intervention
- Effect size
- —
- Significance
- Not reported
- Journal
- Fundación para la Investigación del Hospital Clínico de Valencia
- Published
- Sep 18, 2026
Sources
Primary source
Recorded source passages
Abstract or registry material supplied for assessment; source version 2. This is not a claim of full-text review.
This study aims to investigate the role of skeletal muscle mitochondrial dysfunction in the development of frailty in older adults and to evaluate whether a short-term, supervised resistance training intervention can improve skeletal muscle health and physical function.
The study will include approximately 120 participants comprising older adults with T2DM, healthy older adults, and young healthy controls.
All participants will complete a 6-week supervised resistance training intervention, consisting of two sessions per week.
Assessments performed before and after the intervention will include body composition, muscle morphology, physical performance, muscle strength, frailty, and blood-based biomarkers.
Source versions
Assessment history
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