Higher epigenetic aging clocks associated with periodontitis in adults aged 50+.
This observational study of 1,559 adults aged 50 and older from NHANES (1999-2002) examined the relationship between DNA methylation-based aging clocks and periodontitis using logistic regression. Higher quartiles of PhenoAge and GrimAge2 clocks, and their acceleration measures, were associated with increased odds of periodontitis (odds ratios ranging from 1.96 to 2.80). GrimAge2 showed the highest discriminative ability with an AUC of 0.700.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 15, 2026 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Cohort
- Sample size
- 1,559
- Duration
- —
- Population
- Adults aged ≥50 years from the NHANES database (1999-2002)
- Primary outcome
- Association between DNA methylation-based aging clocks (PhenoAge and GrimAge2) and periodontitis
- Effect size
- PhenoAge (ORquartile4vs1 = 2.507, 95% CI: 1.181-5.324); GrimAge2 (ORquartile4vs1 = 2.796, 95% CI: 1.093-7.154); PhenoAgeAccel (ORquartile4vs1 = 1.958, 95% CI: 1.039-3.689); GrimAge2Accel (ORquartile4vs1 = 2.667, 95% CI: 1.238-5.748); GrimAge2 AUC = 0.700
- Significance
- Significant
- Journal
- Epigenomics
- Published
- Sep 1, 2026
Sources
Primary source
- Epigenomics ↗Peer reviewed
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
Discussion (0)
One thread per scientific event, no matter how many outlets covered it.
No comments yet
Be the first to weigh in on this evidence.