Registry update — unassessed
Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Dec 5, 2025 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill
What it does not prove
- The actual efficacy of metformin for this indication cannot be assessed—no results are provided in the abstract. The study's sample size and statistical power are unknown. Whether any observed effects would translate to clinical benefit or apply to ambulatory older adults outside a bed rest context is not addressed.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- —
- Primary outcome
- —
- Effect size
- —
- Significance
- Not reported
- Journal
- University of Utah
- Published
- Dec 5, 2025
Sources
Primary source
- University of Utah ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
Title: Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging
Journal: University of Utah
Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the mechanisms are not fully known. Metformin used as a preventive strategy to maintain muscle and metabolic health in bed ridden older adults has not been investigated.
Source versions
Assessment history
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