Registry update — unassessed
Multi-Omic Biomarkers of Response to an Integrated Intervention (Home-Based Multicomponent Exercise Plus Creatine and/or Beta-Hydroxy-Beta-Methylbutyrate [HMB] Supplementation) to Reduce Sarcopenia and Preserve Muscle and Functional Capacity in Huntington's Disease: A Randomized, Double-Blind, Placebo-Controlled, Four-Arm Trial
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Oct 28, 2026 · Discovered: Oct 28, 2026 · Assessed: — · Research update
What it does not prove
- This is a study protocol with no reported results—it describes planned methods and objectives, not actual findings. No efficacy, safety, or biomarker data are presented. The durability assessment at 6 months post-intervention is planned but not yet reported.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 12 months
- Population
- Adults with Huntington's disease and physical frailty/sarcopenia
- Primary outcome
- Functional capacity, neuromuscular performance, body composition, cognition and quality of life
- Effect size
- —
- Significance
- Not reported
- Journal
- Universidad de Burgos
- Published
- Oct 28, 2026
Sources
Primary source
- Universidad de Burgos ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
This randomized, double-blind, placebo-controlled, four-arm parallel trial will include adults with HD and physical frailty/sarcopenia. All participants will follow a 12-week individualized, home-based multicomponent exercise program (VIVIFRAIL-based, with weekly remote monitoring) and will be randomized 1:1:1:1 to placebo, creatine (CRE), beta-hydroxy-beta-methylbutyrate (HMB) or combined CRE+HMB.
Durability of effects will be assessed 6 months after the end of the intervention.
Assessment history
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