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Metformin
Registry update — unassessed

Randomized Controlled Trial of Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome

Trial registry update: COMPLETED. No results reported in the supplied registry record.

RCTNotable significance
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Reporter brief

What this changes

The finding has not established an approved change to our evidence assessment.

Source date: Sep 28, 2021 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill

What it does not prove

  • No findings are reported in the available material, so no causal or preventive effects can be evaluated.
  • The sample size and effect sizes are not provided, preventing assessment of statistical power or clinical significance.
  • As an abstract-only source, this does not present the full study protocol, outcomes, or any completed analyses.

Extracted from supplied source material; model confidence is not a measured probability of correctness.

Study details

Design
Rct
Sample size
—
Duration
—
Population
Men and women with Metabolic syndrome (MetS)
Primary outcome
Prevention of age-related chronic non-communicable diseases (ArCD)
Effect size
—
Significance
Not reported
Journal
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Published
Sep 28, 2021

Sources

Primary source

Recorded source passages

Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.

Phase III randomized controlled trial on men and women with Metabolic syndrome (MetS) to test the hypothesis that comprehensive life-style changes and/or metformin treatment prevent age-related chronic non-communicable diseases (ArCD).
The aim of the present study is to evaluate the effect of a comprehensive life-style intervention (including moderate physical activity and Mediterranean/macrobiotic diet with moderate calorie and protein restriction), and of treatment with Metformin (a calorie restriction mimetic drug) for the prevention of ArCD.

Source versions

Version 1: Superseded

Version 1: Unassessed

Assessment history

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