Registry update — unassessed
Role of Exercise and Low-Dose Rapamycin on Age-Associated Impairments in Older Adults With Coronary Artery Disease: Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial
Trial registry update: COMPLETED. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Dec 7, 2016 · Discovered: Sep 19, 2026 · Assessed: — · Historical research backfill
What it does not prove
- This is a protocol describing a planned trial, not a completed study with results—no efficacy or safety data are reported
- The pilot phase sample size is very small (up to 18 total, with only 6 per dose group), limiting ability to detect effects or establish safe dosing
- The decision to proceed to Phase 2 depends on unspecified criteria for 'favorable changes' in senescent markers, introducing bias into trial initiation
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Patients aged 60 years or older with coronary artery disease undergoing percutaneous coronary intervention (PCI), coronary artery bypass surgery (CABG), or eligible to participate in cardiac rehabilitation
- Primary outcome
- Frailty (age-associated impairment); Phase 2 also tests measures of age-associated impairment (AAI) and senescent-associated secretory phenotype (SASP)
- Effect size
- —
- Significance
- Not reported
- Journal
- Mayo Clinic
- Published
- Dec 7, 2016
Sources
Primary source
- Mayo Clinic ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
The investigators will do the study in two phases. The first phase will be a pilot study on up to 18 participants
up to 6 participants each will be given oral daily rapamycin (0.5, 1, and 2mg) dose for the duration of CR
In a prospective, randomized, clinical trial design, patients 60 years or older will be randomized at the time of CR to a standardized exercise protocol, or exercise protocol with the addition of low-dose rapamycin
Source versions
Assessment history
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