Registry update — unassessed
Sirolimus in Older Adults- Randomized Trial Assessing the Improvement in Phenotypic/Functional Biomarkers of Aging
Trial registry update: RECRUITING. No results reported in the supplied registry record.
RCTRoutine significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Jun 25, 2026 · Discovered: Sep 18, 2026 · Assessed: — · Historical research backfill
What it does not prove
- No efficacy or safety data are presented, making this a protocol or preliminary description rather than a completed trial report
- The absence of results precludes any conclusion about whether rapamycin actually affects aging biomarkers or clinical outcomes in older adults
- The stated hypothesis about mTOR inhibition slowing aging is based on animal studies and theory, not demonstrated clinical evidence from this trial
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Older adults
- Primary outcome
- Reduction in biomarkers of aging processes
- Effect size
- —
- Significance
- Not reported
- Journal
- NOT_REPORTED
- Published
- Jun 25, 2026
Sources
Primary source
- Irina Timofte ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
The proposed study addresses critical gaps in our understanding of the safety and efficacy of sirolimus in delaying aging processes and is based on findings in animal studies and incidental clinical observations. The investigators will overcome potential biases with a randomized control trial.
Specifically, the investigators aim to investigate whether sirolimus can reduce the occurrence or increase in biomarkers of aging processes.
Source versions
Assessment history
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