Systematic review finds testosterone signaling affects cardiovascular disease through multiple mechanisms
This systematic review examined the relationship between androgens (particularly testosterone) and cardiovascular disease in aging adults. The authors surveyed the literature on testosterone's genomic and non-genomic signaling mechanisms in the cardiovascular system and reviewed evidence on how exogenous testosterone treatment and androgen deprivation therapy affect cardiovascular outcomes. The review identified associations between androgen levels and various cardiovascular conditions including cardiac hypertrophy, heart failure, atherosclerosis, aortic valve disease, and aneurysms.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 17, 2026 · Discovered: Sep 18, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Systematic review
- Sample size
- —
- Duration
- —
- Population
- The review addresses androgen physiology and cardiovascular disease relationships in adults of varying ages, with particular attention to aging adults and consideration of both males and females; specific demographic details are not provided in the abstract.
- Primary outcome
- —
- Effect size
- —
- Significance
- Not reported
- Journal
- Cardiovascular engineering and technology
- Published
- Sep 17, 2026
Sources
Primary source
- Cardiovascular engineering and technology ↗Peer reviewed
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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