Systematic review of sex and age differences in ischemic stroke molecular pathology and therapeutic response
This systematic review examined how biological sex and aging shape molecular mechanisms in ischemic stroke, emphasizing sex-specific cell death pathways, mitochondrial dysfunction, and NAD+-sirtuin signaling. The authors describe how premenopausal females show caspase-dependent apoptosis while males exhibit PARP-1-mediated parthanatos, and how postmenopausal females lose neuroprotective advantages due to estrogen receptor changes and mitochondrial decay. The review proposes precision medicine approaches including ER-alpha modulators, NAD+ precursors, and senolytic combinations tailored to sex and reproductive stage.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 16, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Systematic review
- Sample size
- —
- Duration
- —
- Population
- Humans with ischemic stroke across the lifespan, stratified by biological sex and reproductive age
- Primary outcome
- Sex-specific and age-dependent molecular pathophysiology in ischemic stroke and differential therapeutic responsiveness
- Effect size
- —
- Significance
- Not reported
- Journal
- Progress in Neurobiology
- Published
- Sep 16, 2026
Funding: Not reported
Conflicts: Not reported
Sources
Primary source
- Progress in neurobiology ↗Peer reviewed
Assessment history
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