Assessment superseded
The Effects of Regular Exercise Training on Biological Aging in Older Adults: Investigation of Epigenetic and Functional Changes
Trial registry update: COMPLETED. No results reported in the supplied registry record.
COHORTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 2, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- The study design is cohort without a control group; no comparison group receiving usual care or alternative intervention is reported, so causality and the magnitude of exercise-specific effects cannot be determined.
- Results of the analysis are not reported in the provided material—only study design and planned measurements are described—so what changes actually occurred in biological age or other outcomes remains unknown.
- Whether observed associations, if any, reflect genuine slowing of aging processes versus measurement noise or regression to the mean cannot be determined from the information provided.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Cohort
- Sample size
- —
- Duration
- 6 months
- Population
- Adults aged 50-70 years
- Primary outcome
- Association between individual volume of exercise performed (quantified as MET-hours) and changes in blood DNA methylation-based biological age acceleration (measured via DNAmFitAge, DNAmPhenoAge, DNAmGrimAge, Hannum Age, DunedinPACE, Horvath Skin & Blood and pan-tissue clocks)
- Effect size
- —
- Significance
- Not reported
- Journal
- Hungarian University of Sports Science
- Published
- Sep 2, 2026
Sources
Primary source
- Hungarian University of Sports Science ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body composition, metabolic health, and the gut microbiome in adults aged 50-70 years.
Participants completed supervised exercise training three times per week for 6 months.
High-intensity intervals were performed above approximately 80% of estimated HRmax and were separated by 2-minute periods of active recovery.
The primary overall objective of the study was to determine whether the individual volume of exercise performed, quantified as MET-hours, was associated with changes in blood DNA methylation-based biological age acceleration following the 6-month intervention.
Source versions
Assessment history
9/24/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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