Time-restricted eating showed no reported effects on cancer-related fatigue in a phase II RCT protocol.
This is a protocol paper describing a planned 12-week randomized controlled trial (THYME study) comparing time-restricted eating (10-hour daytime eating window) versus nutrition counseling in 132 adults aged 55+ with prostate or metastatic breast cancer. The study aims to assess effects on fatigue, frailty, and circadian rhythm markers, with planned follow-up at 12 weeks and 12 months. No results from the trial are reported in this abstract—only the study design and hypotheses are presented.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 17, 2026 · Discovered: Sep 19, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- 132
- Duration
- 12 months
- Population
- Patients aged 55 years or older with prostate cancer or metastatic breast cancer, with baseline eating window >12 hours, not employed in night-shift work
- Primary outcome
- Patient-reported fatigue
- Effect size
- —
- Significance
- Not reported
- Journal
- University of Maryland, Baltimore
- Published
- Sep 17, 2026
Sources
Primary source
- University of Maryland, Baltimore ↗Clinical trial
Source versions
Assessment history
9/24/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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