Registry update — unassessed
Vaccination Efficacy With Metformin in Older Adults: A Pilot Study
Trial registry update: COMPLETED. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Jul 23, 2020 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill
What it does not prove
- The abstract provided contains no reported findings, so it is impossible to assess what the study does or does not prove about metformin's effect on vaccine response
- Sample size is not reported, limiting ability to interpret statistical power and generalisability
- Effect sizes are not reported, preventing assessment of the magnitude of any differences between groups
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 22 months
- Population
- Older adults (men and women)
- Primary outcome
- Immune responses to flu vaccine
- Effect size
- —
- Significance
- Not reported
- Journal
- UConn Health
- Published
- Jul 23, 2020
Sources
Primary source
- UConn Health ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
With aging the immune system gets weaker. This makes older adults more susceptible to influenza (flu).
This research is being done to determine if Metformin, an FDA-approved diabetes medication, is effective at enhancing immune responses to flu vaccine in older men and women.
Participants will be randomly assigned to either metformin or placebo treatment for a total of 22 weeks.
Participants will be vaccinated with high-dose flu vaccine after 12 weeks of treatment.
Immune responses will be evaluated throughout the study at 6 time points.
Source versions
Assessment history
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