Research feed
Understand the finding first, then explore the evidence. Choose your reading level and sources independently.
Advanced research filters
Dates show original publication, separately from when we added the story. Clinical trials lists registry activity separately. Check collection coverage.
- Research review· Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Systematic review describes growth hormone receptor signaling mechanisms and Laron syndrome as a model of GH deficiency effects.
This systematic review examines the growth hormone-IGF-I axis and its role in growth, metabolism, and tissue homeostasis. The review synthesizes knowledge of growth hormone receptor structure, signal transduction pathways (JAK2-STAT5, MAPK/ERK, PI3K-AKT-mTOR), and discusses Laron syndrome—a condition of lifelong GHR deficiency—as a human model showing that GH deficiency associates with short stature but also enhanced insulin sensitivity, preserved glucose homeostasis, increased adiposity, and low cancer incidence.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society ↗