Systematic review describes growth hormone receptor signaling mechanisms and Laron syndrome as a model of GH deficiency effects.
This systematic review examines the growth hormone-IGF-I axis and its role in growth, metabolism, and tissue homeostasis. The review synthesizes knowledge of growth hormone receptor structure, signal transduction pathways (JAK2-STAT5, MAPK/ERK, PI3K-AKT-mTOR), and discusses Laron syndrome—a condition of lifelong GHR deficiency—as a human model showing that GH deficiency associates with short stature but also enhanced insulin sensitivity, preserved glucose homeostasis, increased adiposity, and low cancer incidence.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 4, 2026 · Discovered: Sep 14, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Systematic review
- Sample size
- —
- Duration
- —
- Population
- General review of growth hormone-IGF axis physiology, with specific reference to patients with Laron syndrome (GHR deficiency) from an Ecuadorian cohort
- Primary outcome
- Physiological roles of the GH-IGF axis in growth, metabolism, and disease (cancer)
- Effect size
- —
- Significance
- Not reported
- Journal
- Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
- Published
- Sep 4, 2026
Sources
Assessment history
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