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- Animal research· Frontiers in immunology
Systematic review finds platelet factor 4 modulates cognitive, immune, and hematopoietic aging through multiple signaling pathways.
This systematic review examined evidence for platelet factor 4 (PF4) in age-related dysfunction across cognitive, immune, and hematopoietic systems. The authors report that PF4 engages CXCR3 and LDLR receptors to activate downstream signaling, with reported effects including reduced hippocampal neuroinflammation, enhanced synaptic plasticity, restored T-cell balance, and preserved hematopoietic stem cell function in aging. Clinical observational studies identified correlations between circulating PF4 levels and conditions including Alzheimer's disease, sarcopenia, stroke, and coronary artery disease.
Evidence assessment pending
Read the study · Frontiers in immunology ↗ - Observational study· Neuropsychobiology
Emotional neglect linked to brain proteins and thinking problems in depressed teens
Adolescents with mood disorders and emotional neglect showed lower levels of an anti-aging protein (Klotho) and higher levels of an inflammatory protein (MMP-9), along with weaker working memory and decision-making abilities.
Why it matters: Understanding which types of childhood hardship affect brain development could guide better support for teenagers with mood disorders.
AI-assisted explanation · Evidence assessment pending
Read the study · Neuropsychobiology ↗