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- Observational study· Translational psychiatry
Healthy lifestyle associated with longer telomeres in severe mental disorders, observational study of 410 patients
This observational study of 410 individuals with schizophrenia spectrum or affective disorders examined whether lifestyle factors were associated with telomere length, a marker of cellular ageing. Participants reporting healthy lifestyles had significantly longer telomeres than those reporting unhealthy lifestyles (Cohen's d = 0.58, p = 0.004), with an apparent dose-response relationship between increasing unhealthy behaviours and shorter telomeres (p = 0.02). The observed difference corresponded to approximately 6 years of biological age.
Evidence assessment pending
Read the study · Translational psychiatry ↗ - Research paper· Tobacco induced diseases
Cigarette smoke triggers lung aging through a cellular stress pathway
Cigarette smoke activates a protein called aryl hydrocarbon receptor in lung cells, which causes damaging molecules to accumulate and impairs cells' cleaning systems, leading to permanent cellular aging linked to COPD.
Why it matters: Understanding this smoke-damage pathway could point to new targets for treating or slowing the lung disease caused by smoking.
AI-assisted explanation · Evidence assessment pending
Read the study · Tobacco induced diseases ↗