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- Observational study· Translational psychiatry
Healthy lifestyle associated with longer telomeres in severe mental disorders, observational study of 410 patients
This observational study of 410 individuals with schizophrenia spectrum or affective disorders examined whether lifestyle factors were associated with telomere length, a marker of cellular ageing. Participants reporting healthy lifestyles had significantly longer telomeres than those reporting unhealthy lifestyles (Cohen's d = 0.58, p = 0.004), with an apparent dose-response relationship between increasing unhealthy behaviours and shorter telomeres (p = 0.02). The observed difference corresponded to approximately 6 years of biological age.
Evidence assessment pending · OBSERVATIONAL
Read the study · Translational psychiatry ↗ - Research paper· Tobacco induced diseases
Rapamycin reversed cigarette smoke-induced autophagy impairment in rat lung cells and human cell cultures.
A preclinical study exposed rats to cigarette smoke for 8 weeks and treated human bronchial epithelial cells with cigarette smoke extract to model COPD-related cellular senescence. Rapamycin (an autophagy activator) reversed impaired autophagic flux and cellular senescence markers in both in vivo and in vitro models, while the AhR antagonist CH223191 and ROS scavenger NAC similarly restored autophagy and reduced senescence.
Evidence assessment pending · PRECLINICAL
Read the study · Tobacco induced diseases ↗