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  1. Research review· Frontiers in immunology

    Systematic review finds extracellular vesicles may modulate inflammation and support cartilage repair in osteoarthritis.

    Published Sep 3, 2026Added 1moStart a discussionShare on XStem cell therapy

    This systematic review examined how extracellular vesicles (EVs)—small membrane-enclosed particles carrying cellular cargo—influence osteoarthritis pathology and potential treatment. The authors describe a "pathological EV cycle" in which EVs from inflammatory cells drive cartilage degradation and bone remodeling, while EVs from therapeutic cells like mesenchymal stromal cells may suppress inflammation and promote tissue repair. The review identifies engineering improvements in EV delivery and potency but notes significant limitations in translating this approach to clinical use.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Frontiers in immunology ↗
  2. Research review· Journal of cellular and molecular medicine

    Systematic review examines molecular mechanisms of skin aging and therapeutic approaches including stem cell therapy.

    Published Sep 1, 2026Added 1moStart a discussionShare on XStem cell therapy

    This is a narrative review that describes the phenotypes and mechanisms of skin aging, including reduced regenerative capacity, chronic inflammation, impaired barrier function, oxidative stress, DNA damage, and epigenetic alterations. The authors evaluate recent research on pharmacological interventions and stem cell therapy for mitigating skin aging, along with delivery systems for natural compounds and the potential of AI in drug discovery. No specific efficacy data or effect sizes for stem cell therapy are reported.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Journal of cellular and molecular medicine ↗
  3. Laboratory research· International journal of food science

    Curcumin reduced oxidative stress and promoted neural differentiation in cultured stem cells in vitro.

    Published Sep 20, 2026Added 1moStart a discussionShare on XStem cell therapy

    This in vitro study tested curcumin's effects on C17.2 neural stem cells exposed to oxidative stress. Curcumin-treated cells showed improved survival, reduced reactive oxygen species levels, enhanced antioxidant markers, and promoted differentiation into neurons and astrocytes, with apparent involvement of the Wnt3α/β-catenin/Cyclin D1 signaling pathway.

    Evidence assessment pending · IN VITRO

    Read the study · International journal of food science ↗
  4. Research paper· Molecular genetics and genomics : MGG

    USP22 protein reduces senescence in bone marrow stem cells exposed to oxidative stress in vitro

    Published Sep 17, 2026Added 1moStart a discussionShare on XStem cell therapy

    This in vitro study examined how USP22 affects bone marrow mesenchymal stem cells (BMSCs) exposed to hydrogen peroxide to simulate oxidative stress. Researchers found that USP22 stabilized the SPI1 protein through deubiquitination, which increased NAMPT expression and NAD+ levels, reducing cellular senescence markers and preserving the cells' capacity to differentiate into bone tissue.

    Evidence assessment pending · IN VITRO

    Read the study · Molecular genetics and genomics : MGG ↗