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  23. Research review· Journal of drug targeting

    Review of senescence-associated extracellular vesicles in skin aging and potential therapeutic approaches.

    Published Sep 22, 2026Added 1moStart a discussionShare on XSenolytics

    This is a review article examining the role of senescence-associated extracellular vesicles (SA-EVs) in skin aging and dysfunction. The authors describe how SA-EVs are secreted by senescent cells and carry proinflammatory cargo that promotes further senescence, impairs wound healing, and contributes to chronic wounds, diabetic ulcers, scarring, and skin aging. The review discusses potential therapeutic approaches including senolytics, senomorphics, stem cell-derived EVs, and biomaterial-assisted systems.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Journal of drug targeting ↗
  28. Research review· Progress in neurobiology

    Systematic review of sex and age differences in ischemic stroke molecular pathology and therapeutic response

    Published Sep 16, 2026Added 1moStart a discussionShare on XNMNSenolytics

    This systematic review examined how biological sex and aging shape molecular mechanisms in ischemic stroke, emphasizing sex-specific cell death pathways, mitochondrial dysfunction, and NAD+-sirtuin signaling. The authors describe how premenopausal females show caspase-dependent apoptosis while males exhibit PARP-1-mediated parthanatos, and how postmenopausal females lose neuroprotective advantages due to estrogen receptor changes and mitochondrial decay. The review proposes precision medicine approaches including ER-alpha modulators, NAD+ precursors, and senolytic combinations tailored to sex and reproductive stage.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Progress in neurobiology ↗
  29. Research review· International reviews of immunology

    Systematic review describes nutritional interventions, including omega-3s, as potential modulators of aging-related immune dysfunction.

    Published Sep 16, 2026Added 1moStart a discussionShare on XOmega-3 fatty acids

    This systematic review examines how nutritional interventions—including bioactive compounds, essential nutrients, and functional foods—might modulate immune system aging (immunosenescence) and its effects on organ function. The authors propose an "immune-organ axis" framework linking immune dysregulation to organ-specific dysfunction in conditions like neurodegeneration and chronic inflammation. The review highlights antioxidants from sources like fish oil, berries, turmeric, and algae as potentially beneficial, while noting that bioactive compounds face absorption and stability challenges.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · International reviews of immunology ↗