Diet quality associated with lower CVD incidence and mortality, partially mediated by slower aging in UK cohort study
This prospective cohort study of 52,718 UK Biobank participants followed for a mean of 12 years examined whether accelerated biological aging mediated the association between diet quality (measured by four indices including Mediterranean Diet Score) and cardiovascular disease outcomes. Higher diet quality was associated with lower CVD incidence and mortality, with accelerated aging mediating 21.81–40.84% of the association with incident CVD and 16.67–35.87% of the association with CVD mortality.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 20, 2026 · Discovered: Sep 21, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Cohort
- Sample size
- 52,718
- Duration
- 144 months
- Population
- UK Biobank cohort participants
- Primary outcome
- Incident CVD (cardiovascular disease) and CVD mortality
- Effect size
- Proportion mediated ranged from 21.81 to 40.84% for incident CVD and from 16.67 to 35.87% for CVD mortality
- Significance
- Significant
- Journal
- GeroScience
- Published
- Sep 20, 2026
Sources
Primary source
- GeroScience ↗Peer reviewed
Assessment history
9/24/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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