Assessment superseded
Impact of Aging and Exercise on Glymphatic Function Using Multi-modal MRI
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
OBSERVATIONALMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Aug 20, 2026 · Discovered: Sep 18, 2026 · Assessed: — · Research update
What it does not prove
- The material presents only a protocol or study hypothesis; no actual results are reported, leaving outcomes completely unknown
- Lack of randomization and control group means any observed associations cannot distinguish exercise effects from confounding factors like baseline fitness or motivation
- No sample size, effect sizes, or quantified findings are provided, preventing assessment of statistical power or clinical magnitude
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Observational
- Sample size
- —
- Duration
- —
- Population
- Cognitively unimpaired subjects aged 25-55 and 55-75 years
- Primary outcome
- Glymphatic function assessed via multi-modal MRI; cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange and paravascular cerebrospinal fluid (pCSF) dynamics
- Effect size
- —
- Significance
- Not reported
- Journal
- University of Texas Southwestern Medical Center
- Published
- Oct 5, 2026
Sources
Primary source
- University of Texas Southwestern Medical Center ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
This is a prospective, interventional, non-blinded, single center research project that will recruit cognitively unimpaired subjects in the 25-55 year old and 55-75 year old range.
There will be no randomization, and all enrolled subjects will participate in the exercise session.
This study will use acute aerobic exercise as a natural intervention model to increase cardiac activity which may further drive the glymphatic function.
Source versions
Assessment history
10/5/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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