Klotho levels associated with bone density in women with systemic sclerosis: observational cross-sectional study
This observational cross-sectional study examined whether klotho and related cytokines are associated with bone mineral density and osteoimmunological markers in female patients aged 45-65 with systemic sclerosis, compared to age and gender-matched healthy controls. The study investigates whether these factors relate to the microvascular damage and fibrosis characteristic of systemic sclerosis. No effect sizes, sample sizes, or specific findings are reported in the abstract.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Mar 12, 2025 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Observational
- Sample size
- —
- Duration
- —
- Population
- Female patients aged 45-65 years with systemic sclerosis (SSc) diagnosed according to EULAR/ACR 2013 criteria and age and gender-matched healthy control subjects
- Primary outcome
- Klotho and other cytokines involved in osteoimmunological control of bone turnover as determinants of microvascular damage and fibrosis in SSc patients
- Effect size
- —
- Significance
- Not reported
- Journal
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Published
- Mar 12, 2025
Sources
Primary source
Assessment history
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