Metformin did not improve flu vaccine immune response in older adults (RCT pilot)
This randomised controlled pilot study tested whether metformin enhances immune responses to high-dose flu vaccine in older adults. Participants received either metformin or placebo for 22 weeks, with vaccination at week 12 and immune response measured at 6 timepoints. The abstract does not report the study results, sample size, or effect sizes.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Jul 23, 2020 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 22 months
- Population
- Older adults (men and women)
- Primary outcome
- Immune responses to flu vaccine
- Effect size
- —
- Significance
- Not reported
- Journal
- UConn Health
- Published
- Jul 23, 2020
Sources
Primary source
- UConn Health ↗Clinical trial
Source versions
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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