MOTIVATE study protocol: RCT of exercise and semaglutide on cognition in older adults with type 2 diabetes.
The MOTIVATE study is a randomized trial protocol examining supervised exercise (3 times weekly for 32 weeks) and semaglutide treatment (weekly injections for 16 weeks), alone or combined, versus control in older adults with type 2 diabetes. The study will measure cognitive function via testing, physical outcomes, metabolic markers, and brain imaging to evaluate whether these interventions support cognitive health and physical function in this population.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Aug 20, 2026 · Discovered: Sep 18, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 32 months
- Population
- Older adults with Type 2 diabetes
- Primary outcome
- Cognitive function
- Effect size
- —
- Significance
- Not reported
- Journal
- Western University, Canada
- Published
- Aug 20, 2026
Sources
Primary source
- Western University, Canada ↗Clinical trial
Source versions
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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