Registry update — unassessed
Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Optimizing Surgical Outcomes at UPMC
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
RCTNotable significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Jun 18, 2024 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill
What it does not prove
- The abstract provides no outcome data, effect sizes, or results—only the study protocol and objectives, so it cannot demonstrate whether metformin affects surgical outcomes
- The sample size is not reported, making it impossible to assess statistical power or the study's ability to detect meaningful effects
- As a protocol document rather than a completed study report, this provides no evidence about efficacy or safety of metformin in this population
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Nondiabetic older adults scheduled for elective surgery
- Primary outcome
- Hospital free days at day 90 for adult patients undergoing elective surgery
- Effect size
- —
- Significance
- Not reported
- Journal
- Not peer-reviewed; author listed as Matthew Neal MD
- Published
- Jun 18, 2024
Sources
Primary source
- Matthew Neal MD ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
The purpose of this project is to determine the effect of various interventions to improve patient outcome as defined by hospital free days at day 90 for adult patients undergoing elective surgery.
The SPRY clinical trial will determine the effectiveness of Metformin on improving surgical outcomes among nondiabetic older adults who are scheduled for elective surgery.
the testing of multiple treatments at the same time within the same patient
the use of early study results to provide better treatment options to future patients
the removal of treatments which are shown to be less effective than the other treatments
Source versions
Assessment history
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