Six-month HIIT associated with changes in DNA methylation-based aging measures in adults 50-70 years old
This observational study examined whether exercise volume from a 6-month supervised high-intensity interval training program was associated with changes in DNA methylation-based biological aging measures and other physiological markers in adults aged 50-70 years. Participants completed three supervised sessions weekly, with training intensity individually prescribed and monitored. The study assessed multiple biological aging clocks (DNAmFitAge, DNAmPhenoAge, DNAmGrimAge, Hannum Age, DunedinPACE, and others) along with cardiovascular function, aerobic capacity, muscle performance, body composition, metabolic biomarkers, and gut microbiome composition before and after the intervention.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 2, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Cohort
- Sample size
- —
- Duration
- 6 months
- Population
- Adults aged 50-70 years
- Primary outcome
- Association between individual volume of exercise performed (quantified as MET-hours) and changes in blood DNA methylation-based biological age acceleration (measured via DNAmFitAge, DNAmPhenoAge, DNAmGrimAge, Hannum Age, DunedinPACE, Horvath Skin & Blood and pan-tissue clocks)
- Effect size
- —
- Significance
- Not reported
- Journal
- Hungarian University of Sports Science
- Published
- Sep 2, 2026
Sources
Primary source
- Hungarian University of Sports Science ↗Clinical trial
Source versions
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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