Systematic review: mTOR pathway integrates aging hallmarks; causal lifespan effects shown in model organisms, human evidence associative.

This systematic review examined mTOR signaling as a hub coordinating aging processes across genetic, experimental, and translational studies. In model organisms, mTOR pathway inhibition shows causal effects on lifespan regulation, whereas human data remain predominantly observational and associative. The review identifies mTOR as an integrative node linking multiple aging hallmarks and notes that major geroprotective interventions—including autophagy activation, dietary changes, physical activity, and senotherapeutics—partly converge on but also diverge from mTOR pathway modulation.