Registry update — unassessed
Chronic Metformin Treatment Induces a Dietary Restriction-like State in Overweight Human
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
RCTN=60Minor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Apr 26, 2016 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill
What it does not prove
- The study does not establish whether any observed gene expression changes translate to clinical health benefits or reduced disease risk in humans. The abstract does not report the actual findings, results, or effect sizes, making it impossible to assess what was actually discovered. Small sample size (20 per group) and short duration (6 months) limit generalisability to broader populations and long-term effects.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- 60
- Duration
- 6 months
- Population
- Overweight subjects
- Primary outcome
- Gene expression profile resembling dietary restriction state; blood and muscle samples
- Effect size
- —
- Significance
- Not reported
- Journal
- Xiang Guang-da
- Published
- Apr 26, 2016
Sources
Primary source
- Xiang Guang-da ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
Sixty overweight subjects will be included in this study, and participants will be divided 3 groups (20 cases in each group)including metformin group (0.85, twice daily), standard diet group, and CR group. All subjects will be treated 6 months. At the end of this study, blood samples and muscle samples will be obtained.
Source versions
Assessment history
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