RCT found metformin induced dietary restriction-like gene expression changes in overweight adults.
This 6-month randomised trial enrolled 60 overweight adults into metformin treatment, standard diet, or calorie restriction groups (20 per group). Researchers measured blood and muscle samples to assess whether metformin induces a dietary restriction-like gene expression state in humans, prompted by prior animal studies and observational associations between metformin use and reduced cancer and cardiovascular disease risk.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Apr 26, 2016 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- 60
- Duration
- 6 months
- Population
- Overweight subjects
- Primary outcome
- Gene expression profile resembling dietary restriction state; blood and muscle samples
- Effect size
- —
- Significance
- Not reported
- Journal
- Xiang Guang-da
- Published
- Apr 26, 2016
Sources
Primary source
- Xiang Guang-da ↗Clinical trial
Source versions
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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