RCT testing metformin effect on surgical outcomes in nondiabetic older adults, first adaptive platform trial study
A randomized controlled trial (SPRY study) embedded within an adaptive platform testing multiple interventions for elective surgery patients. The study aims to determine whether metformin improves surgical outcomes, specifically hospital-free days at day 90, in nondiabetic older adults undergoing elective surgery. No results are reported.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Jun 18, 2024 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Nondiabetic older adults scheduled for elective surgery
- Primary outcome
- Hospital free days at day 90 for adult patients undergoing elective surgery
- Effect size
- —
- Significance
- Not reported
- Journal
- Not peer-reviewed; author listed as Matthew Neal MD
- Published
- Jun 18, 2024
Sources
Primary source
- Matthew Neal MD ↗Clinical trial
Source versions
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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