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- Animal research· Signal transduction and targeted therapy
Hepassocin prevents age-related liver senescence in mice via AMPK activation.
This preclinical study examined how Hepassocin (HPS), a hepatokine, affects liver aging and regeneration in mice. Aged HPS-knockout mice showed increased cellular senescence, impaired autophagy, and severely compromised liver regeneration after partial hepatectomy, with these deficits reversible by AMPK activation. The authors identified a signaling pathway (ANXA2-ERK-p90RSK-LKB1) through which HPS activates AMPK, and demonstrated that exogenous HPS improved regenerative outcomes in aged wild-type mice.
Evidence assessment pending · ANIMAL
Read the study · Signal transduction and targeted therapy ↗ - Observational study· The journal of nutrition, health & aging
Epigenetic age acceleration associated with increased pancreatic disease risk in UK Biobank cohort
In 326,873 UK Biobank participants, two measures of biological age acceleration (KDMAgeAccel and PhenoAgeAccel) were associated with increased risk of pancreatic diseases. The highest acceleration group (G4) had 1.7–3.6 times higher hazard ratios across pancreatic outcomes compared to the lowest group (G1), with the strongest associations for chronic pancreatitis (HR 3.551). Circulating lipid biomarkers partially mediated these associations, accounting for 6–9% of the effect.
Evidence assessment pending · COHORT
Read the study · The journal of nutrition, health & aging ↗ - Observational study· Health science reports
Epigenetic aging measures associated with higher mortality in breast cancer cohort study
This cohort study of 399 breast cancer patients from NHANES (1999-2020) examined whether three biological age indicators—calculated from 12 blood-based biomarkers—predicted all-cause mortality over a median 6.67-year follow-up. During this period, 144 deaths occurred. All three measures showed associations with increased mortality: Homeostatic Dysregulation (HR=1.465), Klemera-Doubal Method (HR=1.017), and Phenotypic Age (HR=1.080). Homeostatic Dysregulation performed better for short-term prediction while Phenotypic Age showed better efficacy for longer-term prediction.
Evidence assessment pending · COHORT
Read the study · Health science reports ↗ - Research review· Cardiac failure review
Meta-analysis estimates combined effect of quintuple heart failure therapy reduces cardiovascular death or HF hospitalisation
A cross-trial aggregate-data meta-analysis combined hazard ratios from six Phase III randomised trials to estimate the effect of quintuple disease-modifying therapy (including ACE inhibitors/ARBs, beta-blockers, aldosterone antagonists, SGLT2 inhibitors, and vericiguat) versus conventional therapy in heart failure with reduced ejection fraction. The imputed combined effect showed HR 0.34 (95% CI 0.27–0.42) for cardiovascular death or first heart failure hospitalisation, HR 0.31 for first HF hospitalisation alone, HR 0.47 for cardiovascular death alone, and HR 0.51 for all-cause mortality.
Evidence assessment pending · META ANALYSIS
Read the study · Cardiac failure review ↗ - Observational study· Translational psychiatry
Healthy lifestyle associated with longer telomeres in severe mental disorders, observational study of 410 patients
This observational study of 410 individuals with schizophrenia spectrum or affective disorders examined whether lifestyle factors were associated with telomere length, a marker of cellular ageing. Participants reporting healthy lifestyles had significantly longer telomeres than those reporting unhealthy lifestyles (Cohen's d = 0.58, p = 0.004), with an apparent dose-response relationship between increasing unhealthy behaviours and shorter telomeres (p = 0.02). The observed difference corresponded to approximately 6 years of biological age.
Evidence assessment pending · OBSERVATIONAL
Read the study · Translational psychiatry ↗ - Observational study· Journal of behavioral medicine
Threat-related early adversity associated with impaired danger-safety discrimination in adolescents
This observational study of 168 youth examined whether different types of early life adversity (threat vs. deprivation) were associated with fear responses and accelerated biological aging. Threat-related adversity was associated with impaired discrimination between danger and safety cues during fear conditioning and with greater left amygdala activation to negative stimuli. However, the study found no evidence that fear responses explained the link between threat and accelerated biological aging (advanced puberty or epigenetic age).
Evidence assessment pending · OBSERVATIONAL
Read the study · Journal of behavioral medicine ↗ - Research paper· Tobacco induced diseases
Rapamycin reversed cigarette smoke-induced autophagy impairment in rat lung cells and human cell cultures.
A preclinical study exposed rats to cigarette smoke for 8 weeks and treated human bronchial epithelial cells with cigarette smoke extract to model COPD-related cellular senescence. Rapamycin (an autophagy activator) reversed impaired autophagic flux and cellular senescence markers in both in vivo and in vitro models, while the AhR antagonist CH223191 and ROS scavenger NAC similarly restored autophagy and reduced senescence.
Evidence assessment pending · PRECLINICAL
Read the study · Tobacco induced diseases ↗ - News coverage· The Guardian
‘In parks you only see dogs, never children’: can Bogotá adapt to its ageing population?
The Guardian reports on this topic. Open the source for the full explanation.
Source coverage · not an evidence rating
Read the article · The Guardian ↗ - News coverage· BBC News
Why 'sleepmaxxing' could be making your sleep worse
BBC News reports on this topic. Open the source for the full explanation.
Source coverage · not an evidence rating
Read the article · BBC News ↗ - Laboratory research· Frontiers in pharmacology
Lavandula stoechas subsp. luisieri essential oil decreased senescence markers in cultured skin fibroblasts.
In vitro study testing two Lavandula essential oils on etoposide-induced senescent human skin fibroblasts. L. stoechas subsp. luisieri reduced multiple senescence markers (β-galactosidase activity, nuclear alterations, SASP secretion, cell cycle inhibitor expression, and ultrastructural changes) at concentrations as low as 6.25 μg/mL, with greater efficacy than L. pedunculata.
Evidence assessment pending · IN VITRO
Read the study · Frontiers in pharmacology ↗ - Laboratory research· Chemistry & biodiversity
Linum strictum seed oil showed α-amylase inhibition comparable to acarbose in in vitro testing.
This in vitro study characterized the fatty acid composition of Linum strictum seed oil and tested its biological activities. The oil's α-amylase inhibition reached 85.98% with an IC50 of 0.0134 mg/mL, which the authors report as comparable to acarbose. The study also found antibacterial activity against several strains, >70% biofilm inhibition against A. baumannii, and anticoagulant effects.
Evidence assessment pending · IN VITRO
Read the study · Chemistry & biodiversity ↗ - News coverage· The Guardian
Caregiver creep: how helping elderly relatives can snowball into a full-time job
The Guardian reports on this topic. Open the source for the full explanation.
Source coverage · not an evidence rating
Read the article · The Guardian ↗ - Animal research· Nature communications
HMGA1-HP1β peptide therapy extended lifespan in a mouse model of Hutchinson-Gilbert progeria syndrome
Researchers studied the HMGA1-HP1β regulatory axis in a mouse model of Hutchinson-Gilford progeria syndrome (LmnaG609G/G609G mice). They developed a peptide called UHP based on the HMGA1-HP1β binding region and found it reduced cellular senescence markers and significantly extended lifespan in the progeria mice, reportedly by stabilizing HP1β and suppressing senescence-associated secretory factors.
Evidence assessment pending · ANIMAL
Read the study · Nature communications ↗ - Animal research· Nature communications
STING inhibitor H-151 extended lifespan and reduced aging phenotypes in progeroid mice.
Researchers studied the LMNA-CK2α-STING signaling axis in aging using mouse models of progeria. Pharmacologic STING inhibition (H-151) in vivo rescued progeroid phenotypes including bone density loss and multi-tissue senescence, and extended lifespan. The authors found that controlled attenuation of STING signaling was more effective than complete STING ablation.
Evidence assessment pending · PRECLINICAL
Read the study · Nature communications ↗ - Observational study· Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Prolonged sedentary time with few breaks associated with higher cardiovascular mortality and CVD incidence in observational cohort.
This prospective cohort study of 89,010 UK Biobank participants with wearable accelerometer data found that prolonged sedentary time (≥10 hours/day) with infrequent breaks (<12 bouts/day) was associated with a 51.5% higher risk of all-cause mortality, 55.3% higher cardiovascular mortality risk, and 10% higher CVD incidence risk compared to the least sedentary group, during 8 years of follow-up. At age 50, this sedentary pattern was associated with loss of 2.8 years in men and 3.1 years in women of CVD-free life expectancy. More frequent interruptions to sedentary time attenuated these risks.
Evidence assessment pending · COHORT
Read the study · Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences ↗