Interventions
Where each approach stands and the latest research in our collection. Every overview links to its background sources and recent updates; detailed AI reviews are available where completed.
40 tracked topics · AI-written overviews, not expert-reviewed · Recent updates cover the last 30 days.
- Cold exposure
Accessible · 0 collected reports
Cold-water immersion is being studied for effects on stress, wellbeing and recovery. The research remains limited and uses varied methods, making broad claims difficult to assess. A short-term physiological response or improved wellbeing is not proof of slower ageing; meaningful long-term benefits and the balance of benefit and risk need separate evidence. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Creatine
Accessible · 1 collected reports
Creatine has useful evidence for high-intensity exercise performance and adaptations to strength training. These outcomes can matter for physical capacity, but performance or lean-mass benefits do not demonstrate longer life. Its role on a longevity site is therefore mainly as a possible aid to maintaining function, with broader ageing claims requiring their own evidence. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Hearing correction
Accessible · 0 collected reports
Treating hearing loss improves access to sound and communication. In the ACHIEVE study, hearing intervention slowed cognitive decline in participants at higher risk, while the overall trial did not show the same clear cognitive benefit. This is promising evidence for a particular group, rather than proof that hearing aids prevent dementia in everyone. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Nicotinamide riboside
Accessible · 12 collected reports
Nicotinamide riboside is another way researchers try to raise NAD levels. A small randomized trial in middle-aged and older adults showed that it raises blood NAD, with exploratory findings that motivated further cardiovascular research. Successfully changing a molecule is an early research step; the clinical benefits and implications for lifespan require separate demonstration. Source ↗ Recently: The latest trial-registry update in our collection is dated Oct 27, 2026: “FEAST and HOPE: Redox PSC Pilot Study in PSC”. Its implications have not yet been summarized in a source-checked review. Read update ↗
AI review not yet available
Explore research → - NMN
Accessible · 2 collected reports
NMN is a precursor of NAD, a molecule involved in cellular metabolism. Small human trials have shown that supplementation can raise blood NAD and have examined short-term functional outcomes. These trials do not establish that raising NAD makes people live longer, and brief tolerability findings cannot settle the safety of years of use. Source ↗ Recently: The latest trial-registry update in our collection is dated Oct 7, 2026: “Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults”. Its implications have not yet been summarized in a source-checked review. Read update ↗
AI review not yet available
Explore research → - Omega-3 fatty acids
Accessible · 3 collected reports
Omega-3 fatty acids are studied for cardiovascular health, but results vary across populations and preparations. Prescription products, ordinary fish-oil supplements and eating fish are not interchangeable interventions. The useful question is which product improves which clinical outcome in which population, rather than assuming that a change in blood fats means a general longevity benefit. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Periodontal health
Accessible · 0 collected reports
Preventing and treating gum disease protects the tissues that support teeth and helps preserve oral health. That practical benefit should not depend on a longevity claim. Links between oral health and wider disease are a separate research question; evidence that dental treatment improves gums is not, by itself, evidence that it prevents dementia or extends life. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Sauna
Accessible · 0 collected reports
Frequent sauna use was associated with lower cardiovascular and overall mortality in a long-running Finnish study of men. The finding is interesting, but participants were not randomly assigned to use a sauna: differences in health and lifestyle could help explain the result. It supports further study rather than a promise that sauna sessions extend life. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Spermidine
Accessible · 1 collected reports
Spermidine is being investigated as a possible way to influence cellular maintenance. Human supplement research includes small, short trials, such as a study examining tolerability and blood chemistry over weeks. Such work can inform further trials, but it cannot establish prevention of age-related disease, long-term safety or life extension. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Taurine
Accessible · 0 collected reports
Taurine attracted longevity interest, but a key part of its ageing story has been challenged. NIH researchers reported in 2025 that circulating levels did not consistently decline with age and were inconsistently related to health outcomes. That weakens a simple “replace what ageing removes” explanation; it does not, by itself, settle whether supplementation has useful clinical effects. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research → - Vitamin D
Accessible · 0 collected reports
Vitamin D has an established role in bone health, and inadequate levels matter. That does not make extra supplementation a universal ageing treatment: studies of disease prevention in people who already have adequate levels have not consistently supported the broad benefits suggested by observational associations. Correcting a deficiency and trying to extend lifespan are different research questions. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI review not yet available
Explore research →
| Intervention | Current state & recent changes | Research & review |
|---|---|---|
| Cold exposure Accessible | Cold-water immersion is being studied for effects on stress, wellbeing and recovery. The research remains limited and uses varied methods, making broad claims difficult to assess. A short-term physiological response or improved wellbeing is not proof of slower ageing; meaningful long-term benefits and the balance of benefit and risk need separate evidence. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 0 collected reports AI review not yet available |
| Creatine Accessible | Creatine has useful evidence for high-intensity exercise performance and adaptations to strength training. These outcomes can matter for physical capacity, but performance or lean-mass benefits do not demonstrate longer life. Its role on a longevity site is therefore mainly as a possible aid to maintaining function, with broader ageing claims requiring their own evidence. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 1 collected reports AI review not yet available |
| Hearing correction Accessible | Treating hearing loss improves access to sound and communication. In the ACHIEVE study, hearing intervention slowed cognitive decline in participants at higher risk, while the overall trial did not show the same clear cognitive benefit. This is promising evidence for a particular group, rather than proof that hearing aids prevent dementia in everyone. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 0 collected reports AI review not yet available |
| Nicotinamide riboside Accessible | Nicotinamide riboside is another way researchers try to raise NAD levels. A small randomized trial in middle-aged and older adults showed that it raises blood NAD, with exploratory findings that motivated further cardiovascular research. Successfully changing a molecule is an early research step; the clinical benefits and implications for lifespan require separate demonstration. Source ↗ Recently: The latest trial-registry update in our collection is dated Oct 27, 2026: “FEAST and HOPE: Redox PSC Pilot Study in PSC”. Its implications have not yet been summarized in a source-checked review. Read update ↗ Explore research → | 12 collected reports AI review not yet available |
| NMN Accessible | NMN is a precursor of NAD, a molecule involved in cellular metabolism. Small human trials have shown that supplementation can raise blood NAD and have examined short-term functional outcomes. These trials do not establish that raising NAD makes people live longer, and brief tolerability findings cannot settle the safety of years of use. Source ↗ Recently: The latest trial-registry update in our collection is dated Oct 7, 2026: “Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults”. Its implications have not yet been summarized in a source-checked review. Read update ↗ Explore research → | 2 collected reports AI review not yet available |
| Omega-3 fatty acids Accessible | Omega-3 fatty acids are studied for cardiovascular health, but results vary across populations and preparations. Prescription products, ordinary fish-oil supplements and eating fish are not interchangeable interventions. The useful question is which product improves which clinical outcome in which population, rather than assuming that a change in blood fats means a general longevity benefit. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 3 collected reports AI review not yet available |
| Periodontal health Accessible | Preventing and treating gum disease protects the tissues that support teeth and helps preserve oral health. That practical benefit should not depend on a longevity claim. Links between oral health and wider disease are a separate research question; evidence that dental treatment improves gums is not, by itself, evidence that it prevents dementia or extends life. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 0 collected reports AI review not yet available |
| Sauna Accessible | Frequent sauna use was associated with lower cardiovascular and overall mortality in a long-running Finnish study of men. The finding is interesting, but participants were not randomly assigned to use a sauna: differences in health and lifestyle could help explain the result. It supports further study rather than a promise that sauna sessions extend life. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 0 collected reports AI review not yet available |
| Spermidine Accessible | Spermidine is being investigated as a possible way to influence cellular maintenance. Human supplement research includes small, short trials, such as a study examining tolerability and blood chemistry over weeks. Such work can inform further trials, but it cannot establish prevention of age-related disease, long-term safety or life extension. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 1 collected reports AI review not yet available |
| Taurine Accessible | Taurine attracted longevity interest, but a key part of its ageing story has been challenged. NIH researchers reported in 2025 that circulating levels did not consistently decline with age and were inconsistently related to health outcomes. That weakens a simple “replace what ageing removes” explanation; it does not, by itself, settle whether supplementation has useful clinical effects. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 0 collected reports AI review not yet available |
| Vitamin D Accessible | Vitamin D has an established role in bone health, and inadequate levels matter. That does not make extra supplementation a universal ageing treatment: studies of disease prevention in people who already have adequate levels have not consistently supported the broad benefits suggested by observational associations. Correcting a deficiency and trying to extend lifespan are different research questions. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged. Explore research → | 0 collected reports AI review not yet available |