Abolere mortem

What actually changed in longevity science

Research worth understanding. News worth reading. A clearer view of living longer.

Longevity landscape

85.7years

Modeled age at death · +2.3 vs reference

Research comparison across study populations—not a personal forecast.

Click a line to see the exact studies that calculate it. Use the tags in the feed to add or remove evidence.

4 selected source groups · 50% effect transfer. Sources include different study populations; their combined effect has not been tested as a treatment package.

Starting ageUS life table

Model assumptions

Include observational evidenceReported benefit carried into modelAdditional overlapping benefitsAssumed effect duration

Effect transfer and overlap are sensitivity assumptions, not measured correction factors. Age and sex change the reference life table; they do not establish treatment eligibility. Shading shows source bounds, not a combined confidence interval.

Nonfatal harms, adherence and treatment interactions are not modeled. Model longevity-scenarios-1.

Methodology & limitations →

What matters now

Important findings, useful explanations, and setbacks worth knowing about.

All stories →

A quieter news window: showing the latest available stories with their original publication dates. Ranking reflects relevance, recency and reader interest—not proof of benefit.

Longevity news

News, research and the studies that currently shape the longevity chart—all in one stream.

Research review· Journal of drug targeting
Review of senescence-associated extracellular vesicles in skin aging and potential therapeutic approaches.
Published Sep 22, 2026Added 1moStart a discussion Share on X Senolytics
This is a review article examining the role of senescence-associated extracellular vesicles (SA-EVs) in skin aging and dysfunction. The authors describe how SA-EVs are secreted by senescent cells and carry proinflammatory cargo that promotes further senescence, impairs wound healing, and contributes to chronic wounds, diabetic ulcers, scarring, and skin aging. The review discusses potential therapeutic approaches including senolytics, senomorphics, stem cell-derived EVs, and biomaterial-assisted systems.
Evidence assessment pending
Read the study · Journal of drug targeting ↗
Research review· Progress in neurobiology
Brain damage from stroke follows different patterns in men and women
Published Sep 16, 2026Added 1moStart a discussion Share on X NMN Senolytics
This review examines how biological sex and aging affect how the brain responds to stroke injury. Before menopause, female brains use different cell-death pathways than male brains; after menopause, women lose earlier protective advantages and show patterns more like older men.
Why it matters: Understanding sex differences in stroke could guide doctors toward personalized treatments based on a patient's sex and age rather than one-size-fits-all approaches.
AI-assisted explanation · Evidence assessment pending
Read the study · Progress in neurobiology ↗
Research review· International reviews of immunology
Systematic review describes nutritional interventions, including omega-3s, as potential modulators of aging-related immune dysfunction.
Published Sep 16, 2026Added 1moStart a discussion Share on X Omega-3 fatty acids
This systematic review examines how nutritional interventions—including bioactive compounds, essential nutrients, and functional foods—might modulate immune system aging (immunosenescence) and its effects on organ function. The authors propose an "immune-organ axis" framework linking immune dysregulation to organ-specific dysfunction in conditions like neurodegeneration and chronic inflammation. The review highlights antioxidants from sources like fish oil, berries, turmeric, and algae as potentially beneficial, while noting that bioactive compounds face absorption and stability challenges.
Evidence assessment pending
Read the study · International reviews of immunology ↗
Research affecting the chart· PubMed
Combined lifestyle factors, all-cause mortality and cardiovascular disease
Published 2020Observational researchGeneral adult evidence
Directly changes the Combined lifestyle chart input
74 studies; 2,584,766 participants in the all-cause mortality analysis.
Study scope and limits
Adults in prospective cohorts; populations and lifestyle definitions varied.
Healthiest versus least-healthy combinations of smoking, activity, diet, weight and alcohol factors.
Observational association, with residual confounding and heterogeneous lifestyle scores. Not the effect of changing an average person’s habits. Alcohol in the score is not a recommendation to drink.
Read the study · PubMed ↗
Research review· Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Growth hormone's receptor controls growth, metabolism, and cancer risk
Published Sep 4, 2026Added 1moStart a discussion Share on X Growth hormone
The growth hormone receptor is the key molecular switch that controls postnatal growth, skeletal development, and metabolism through several cellular signaling pathways. People with lifelong growth hormone receptor deficiency show short stature but also enhanced insulin sensitivity and very low cancer rates.
Why it matters: Understanding how growth hormone signaling affects aging and cancer may reveal new therapeutic targets for metabolic and cancer control.
AI-assisted explanation · Evidence assessment pending
Read the study · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society ↗
Research review· Frontiers in immunology
Age-related muscle decay involves whole-tissue changes, not just fiber shrinkage
Published Sep 4, 2026Added 1moStart a discussion Share on X Exercise Senolytics
Sarcopenia (age-related muscle weakness) develops through multiple interconnected changes in the muscle tissue environment—including inflammation, cellular damage, and reduced repair capacity—that form a self-reinforcing cycle, rather than from muscle fiber shrinkage alone.
Why it matters: Understanding that sarcopenia involves tissue-wide environmental changes could redirect treatment toward earlier, potentially reversible stages rather than only end-stage muscle loss.
AI-assisted explanation · Evidence assessment pending
Read the study · Frontiers in immunology ↗
Research affecting the chart· PubMed
Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality
Published 2025Observational researchGeneral adult evidence
Directly changes the Physical activity chart input
Umbrella review of meta-analyses; equivalent hazard ratio for leisure-time physical activity.
Study scope and limits
Adults in the self-reported leisure-time physical activity syntheses.
Higher versus lower self-reported leisure-time physical activity; contrasts vary across studies.
Authors classify the association as suggestive evidence. Self-report, residual confounding and overlapping reviews limit interpretation. Replaces the combined lifestyle estimate rather than stacking on it.
Read the study · PubMed ↗
Laboratory research· Frontiers in medicine
Cell death and aging may drive kidney scarring through a metabolic loop
Published Sep 3, 2026Added 1moStart a discussion Share on X Senolytics
Two processes in kidney cells—necroptosis (a type of cell death) and senescence (cellular aging)—may work together to cause kidney scarring that current drugs cannot reverse. They form a self-amplifying cycle involving mitochondrial DNA and metabolic changes.
Why it matters: Understanding this mechanism could guide new combination therapies for kidney disease that current treatments fail to address.
AI-assisted explanation · Evidence assessment pending
Read the study · Frontiers in medicine ↗
Research review· Frontiers in immunology
Extracellular vesicles drive and potentially repair osteoarthritis joint damage
Published Sep 3, 2026Added 1moStart a discussion Share on X Stem cell therapy
Osteoarthritis involves inflammation, cartilage breakdown, and bone damage driven partly by cell-derived vesicles carrying inflammatory signals. Therapeutic vesicles from stem cells may counteract this by reducing inflammation and promoting repair, though technical hurdles remain before clinical use.
Why it matters: Understanding how cell vesicles communicate could explain osteoarthritis progression and enable new treatments targeting inflammation and repair.
AI-assisted explanation · Evidence assessment pending
Read the study · Frontiers in immunology ↗
Research affecting the chart· PubMed
Efficacy and safety of more intensive lowering of LDL cholesterol
Published 2010Randomized researchCardiovascular prevention trial populations
Directly changes the Statins chart input
CTT individual participant meta-analysis of 26 trials; about 170,000 participants overall.
Study scope and limits
Participants enrolled in randomized LDL-lowering trials, with varied cardiovascular risk.
Per 1 mmol/L lower LDL cholesterol, across statin versus control and more- versus less-intensive regimens.
Mortality rate ratio is treated as a proportional hazard multiplier in this model. Trial populations and LDL changes differ; not a longevity estimate for healthy people or a prescribing recommendation.
Read the study · PubMed ↗
Animal research· Arthritis & rheumatology (Hoboken, N.J.)
SIRT6-activating drug reduces osteoarthritis severity in aging mice
Published Sep 22, 2026Added 1moStart a discussion Share on X Gene therapy for ageing
In old mice, weekly injections of MDL-800 for 6 months reduced cartilage damage, bone overgrowth, and other signs of osteoarthritis compared to control mice. The drug appeared to reduce DNA damage and activate repair pathways in joint cells.
Why it matters: Osteoarthritis is a common aging-related disease; understanding how to slow joint damage could improve quality of life in older people.
AI-assisted explanation · Evidence assessment pending
Read the study · Arthritis & rheumatology (Hoboken, N.J.) ↗
Animal research· Frontiers in immunology
Systematic review finds platelet factor 4 modulates cognitive, immune, and hematopoietic aging through multiple signaling pathways.
Published Sep 2, 2026Added 1moStart a discussion Share on X Klotho
This systematic review examined evidence for platelet factor 4 (PF4) in age-related dysfunction across cognitive, immune, and hematopoietic systems. The authors report that PF4 engages CXCR3 and LDLR receptors to activate downstream signaling, with reported effects including reduced hippocampal neuroinflammation, enhanced synaptic plasticity, restored T-cell balance, and preserved hematopoietic stem cell function in aging. Clinical observational studies identified correlations between circulating PF4 levels and conditions including Alzheimer's disease, sarcopenia, stroke, and coronary artery disease.
Evidence assessment pending
Read the study · Frontiers in immunology ↗
Research affecting the chart· PubMed
Cardiovascular and Kidney Outcomes and Mortality With Long-Acting GLP-1 Receptor Agonists
Published 2025Randomized researchType 2 diabetes trial populations
Directly changes the GLP-1 agonists chart input
10 randomized trials; 71,351 participants.
Study scope and limits
People with type 2 diabetes in large cardiovascular and kidney outcome trials.
Long-acting GLP-1 receptor agonist versus placebo, on top of trial background care.
Class-level synthesis in type 2 diabetes; not transferable to healthy adults, every agent, or lifelong use. Trials already include other care, so combining effects can double-count benefit.
Read the study · PubMed ↗
Observational study· Neuropsychobiology
Emotional neglect linked to brain proteins and thinking problems in depressed teens
Published Sep 21, 2026Added 1moStart a discussion Share on X Klotho
Adolescents with mood disorders and emotional neglect showed lower levels of an anti-aging protein (Klotho) and higher levels of an inflammatory protein (MMP-9), along with weaker working memory and decision-making abilities.
Why it matters: Understanding which types of childhood hardship affect brain development could guide better support for teenagers with mood disorders.
AI-assisted explanation · Evidence assessment pending
Read the study · Neuropsychobiology ↗
Research affecting the chart· journals.plos.org
SGLT2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes
Published 2023Randomized researchChronic kidney disease trial populations
Directly changes the SGLT2 inhibitors chart input
Systematic review of 14 randomized trials; all-cause mortality is a secondary endpoint.
Study scope and limits
People with chronic kidney disease, with or without type 2 diabetes.
SGLT2 inhibitor plus standard therapy versus placebo or standard therapy.
The 14 trials cover the review as a whole, not necessarily this endpoint. Kidney disease populations differ from the reference life table. Background treatment overlaps with other selections.
Read the study · journals.plos.org ↗

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Epigenetic clocks →Metformin →Senolytics →Smoking cessation →Exercise →SGLT2 inhibitors →Klotho →Air quality →