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What actually changed in longevity science

Research worth understanding. News worth reading. A clearer view of living longer.

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All stories →

3 stories from the past 72 hours. Older stories keep their original dates. Ranking reflects relevance, recency and reader interest—not proof of benefit.

Longevity news

News, research and the studies that currently shape the longevity chart—all in one stream.

  2. Trial registry · no verified findings· City of Hope Medical Center

    The Effect of Exercise and Nicotinamide Riboside on Muscle Health and Insulin Resistance in Adult Survivors of Childhood Cancer With Prediabetes: A Pilot Feasibility Study

    Published Oct 23, 2026Added 2dStart a discussionShare on XExerciseNicotinamide riboside

    Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending

    Read the source · City of Hope Medical Center ↗
  4. Research affecting the chart· PubMed

    Combined lifestyle factors, all-cause mortality and cardiovascular disease

    Published 2020Observational researchGeneral adult evidence
    Directly changes the Combined lifestyle chart input

    74 studies; 2,584,766 participants in the all-cause mortality analysis.

    Study scope and limits

    Adults in prospective cohorts; populations and lifestyle definitions varied.

    Healthiest versus least-healthy combinations of smoking, activity, diet, weight and alcohol factors.

    Observational association, with residual confounding and heterogeneous lifestyle scores. Not the effect of changing an average person’s habits. Alcohol in the score is not a recommendation to drink.

    Read the study · PubMed ↗
  7. Research affecting the chart· PubMed

    Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality

    Published 2025Observational researchGeneral adult evidence
    Directly changes the Physical activity chart input

    Umbrella review of meta-analyses; equivalent hazard ratio for leisure-time physical activity.

    Study scope and limits

    Adults in the self-reported leisure-time physical activity syntheses.

    Higher versus lower self-reported leisure-time physical activity; contrasts vary across studies.

    Authors classify the association as suggestive evidence. Self-report, residual confounding and overlapping reviews limit interpretation. Replaces the combined lifestyle estimate rather than stacking on it.

    Read the study · PubMed ↗
  9. Trial registry · no verified findings· Centenario Hospital Miguel Hidalgo

    Effect of Egg Albumin and Agave Fructan Supplementation Combined With Functional Exercise on Muscle Mass, Physical Function, and Inflammatory Status in Patients Receiving Hemodialysis: A Randomized Controlled Trial

    Published Oct 16, 2026Added 9dStart a discussionShare on XExercise

    Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending

    Read the source · Centenario Hospital Miguel Hidalgo ↗
  10. Research affecting the chart· PubMed

    Efficacy and safety of more intensive lowering of LDL cholesterol

    Published 2010Randomized researchCardiovascular prevention trial populations
    Directly changes the Statins chart input

    CTT individual participant meta-analysis of 26 trials; about 170,000 participants overall.

    Study scope and limits

    Participants enrolled in randomized LDL-lowering trials, with varied cardiovascular risk.

    Per 1 mmol/L lower LDL cholesterol, across statin versus control and more- versus less-intensive regimens.

    Mortality rate ratio is treated as a proportional hazard multiplier in this model. Trial populations and LDL changes differ; not a longevity estimate for healthy people or a prescribing recommendation.

    Read the study · PubMed ↗
  11. Trial registry · no verified findings· University of Salamanca

    Effectiveness of a Combined Strength Training and Progressive Muscle Relaxation Program in Reducing Frailty in Informal Caregivers of People With Alzheimer's Disease: A Randomized Controlled Trial

    Published Oct 16, 2026Added 9dStart a discussionShare on XResistance training

    Trial registry update: COMPLETED. No results reported in the supplied registry record.

    Evidence assessment pending

    Read the source · University of Salamanca ↗
  13. Research affecting the chart· PubMed

    Cardiovascular and Kidney Outcomes and Mortality With Long-Acting GLP-1 Receptor Agonists

    Published 2025Randomized researchType 2 diabetes trial populations
    Directly changes the GLP-1 agonists chart input

    10 randomized trials; 71,351 participants.

    Study scope and limits

    People with type 2 diabetes in large cardiovascular and kidney outcome trials.

    Long-acting GLP-1 receptor agonist versus placebo, on top of trial background care.

    Class-level synthesis in type 2 diabetes; not transferable to healthy adults, every agent, or lifelong use. Trials already include other care, so combining effects can double-count benefit.

    Read the study · PubMed ↗
  14. Trial registry · no verified findings· University of Illinois at Chicago

    Training the Aging Brain Through Speed: Examining Cerebrovascular Adaptations Associated With Motor-Cognitive Performance Following High-Velocity Resistance Training in Older Adults at Risk for AD/ADRD

    Published Oct 14, 2026Added 11dStart a discussionShare on XResistance training

    Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending

    Read the source · University of Illinois at Chicago ↗
  15. Research affecting the chart· journals.plos.org

    SGLT2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes

    Published 2023Randomized researchChronic kidney disease trial populations
    Directly changes the SGLT2 inhibitors chart input

    Systematic review of 14 randomized trials; all-cause mortality is a secondary endpoint.

    Study scope and limits

    People with chronic kidney disease, with or without type 2 diabetes.

    SGLT2 inhibitor plus standard therapy versus placebo or standard therapy.

    The 14 trials cover the review as a whole, not necessarily this endpoint. Kidney disease populations differ from the reference life table. Background treatment overlaps with other selections.

    Read the study · journals.plos.org ↗
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