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- Trial registry · no verified findings· Odense University Hospital
SENolytics to Improve Osteoporosis Therapy: a Randomised Controlled Clinical Trial The SENIOR Trial
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Odense University Hospital ↗ - Trial registry · no verified findings· Cedars-Sinai Medical Center
A PHASE II, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE ONGOING LUNG DECLINE WITH AGE INTENSIFIED RESPONSE (OLD AIR)
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Cedars-Sinai Medical Center ↗ - Trial registry · no verified findings· University of Colorado, Boulder
Targeting Cellular Senescence With Fisetin for Improving Vascular Endothelial Function in Older Adults
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · University of Colorado, Boulder ↗ - Trial registry · no verified findings· St. Jude Children's Research Hospital
SEN-SURVIVORS: An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · St. Jude Children's Research Hospital ↗ - Trial registry · no verified findings· University of Colorado, Boulder
Clinical Translation of Senolytic Therapy With Fisetin to Improve Vascular Function in Older Adults
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · University of Colorado, Boulder ↗ - Trial registry · no verified findings· National Institute of Allergy and Infectious Diseases (NIAID)
Improving Physical Ability and Cellular Senescence Elimination in HIV
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · National Institute of Allergy and Infectious Diseases (NIAID) ↗ - Trial registry · no verified findings· University of Minnesota
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · University of Minnesota ↗ - Trial registry · no verified findings· Jonsson Comprehensive Cancer Center
A Phase II Randomized Placebo-Controlled Study of Fisetin and Exercise to Prevent Frailty in Breast Cancer Survivors
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Jonsson Comprehensive Cancer Center ↗ - Trial registry · no verified findings· Jonsson Comprehensive Cancer Center
A Phase II Randomized Double-Blind Placebo-Controlled Study of Fisetin to Improve Physical Function in Breast Cancer Survivors
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Jonsson Comprehensive Cancer Center ↗ - Trial registry · no verified findings· Avni Joshi
Senolytics as a Novel Treatment for Interstitial Lung Disease in Common Variable Immunodeficiency (CVID)
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Avni Joshi ↗ - Trial registry · no verified findings· Mayo Clinic
ALSENLITE: An Open-Label Pilot Study of Senolytics for Alzheimer's Disease
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Ove Andersen
Pharmacokinetics, Safety, and Efficacy of Fisetin - A Phase I and Pilot Phase IIa Study
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Ove Andersen ↗ - Trial registry · no verified findings· Mayo Clinic
Senescence, Frailty, and Mesenchymal Stem Cell Functionality in Chronic Kidney Disease: Effect of Senolytic Agents
Trial registry update: ENROLLING_BY_INVITATION. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Mayo Clinic
Fisetin reduced inflammatory markers in elderly women with gait disturbance in a phase 2 RCT
AFFIRM was a phase 2 randomized placebo-controlled trial testing fisetin (a senolytic) in older women with gait disturbance. The study aimed to evaluate effects on insulin resistance markers, inflammation, bone resorption, and physical dysfunction. Specific results were not reported in the provided abstract.
Evidence assessment pending
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Northwestern University
Fisetin to Reduce Senescence and Mobility Impairment in Peripheral Artery Disease: the FIRST Pilot Randomized Trial
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Northwestern University ↗ - Trial registry · no verified findings· Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Dasatinib and Quercetin, a Combination of Senolytics to Treat Fibrotic Non-alcoholic Fatty Liver Disease - the TRUTH Study
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) ↗ - Trial registry · no verified findings· Washington University School of Medicine
Phase II Clinical Trial to Evaluate the Safety and Feasibility of Senolytic Therapy in Alzheimer's Disease
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Washington University School of Medicine ↗ - Trial registry · no verified findings· Cedars-Sinai Medical Center
Single Nuclei RNA-sequencing to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Cedars-Sinai Medical Center ↗ - Trial registry · no verified findings· Washington University School of Medicine
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Washington University School of Medicine ↗ - Trial registry · no verified findings· Ohio State University
Senolytics to Improve Physical and Cognitive Function in Older Adults With Multiple Sclerosis
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Ohio State University ↗ - Trial registry · no verified findings· Mayo Clinic
COVID-FISETIN: A Phase 2 Placebo-Controlled Pilot Study in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Hospitalized Adults
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Mayo Clinic
COVID-FIS: A Phase 2 Placebo-Controlled Pilot Study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
Evidence assessment pending
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Austin V Stone
Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair
Trial registry update: WITHDRAWN. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Austin V Stone ↗ - Trial registry · no verified findings· Steadman Philippon Research Institute
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending
Read the source · Steadman Philippon Research Institute ↗ - Trial registry · no verified findings· Sundeep Khosla, M.D.
Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans: A Phase 2, Single-Center, 20-week, Open-Label, Randomized Controlled Trial.
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending
Read the source · Sundeep Khosla, M.D. ↗ - Trial registry · no verified findings· Qualia Life Sciences
An Open-Label Pilot Study of Qualia Senolytic Supplementation for the Attenuation of Systemic Inflammatory Cytokines
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Qualia Life Sciences ↗ - Trial registry · no verified findings· Lewis Lipsitz
Senolytics To Alleviate Mobility Issues and Neurological Impairment in Aging
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending
Read the source · Lewis Lipsitz ↗ - Trial registry · no verified findings· Steadman Philippon Research Institute
The Use of Senolytic Agent to Improve the Benefit of Platelet-Rich Plasma and Losartan for Treatment of Femoroacetabular Impingement and Labral Tear: A Pilot Study
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Steadman Philippon Research Institute ↗ - Trial registry · no verified findings· Steadman Philippon Research Institute
The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending
Read the source · Steadman Philippon Research Institute ↗ - Trial registry · no verified findings· Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
RCT of immunotherapy plus senolytics versus control before head and neck cancer surgery
A Phase II randomised controlled trial evaluated tislelizumab (anti-PD-1 antibody) combined with dasatinib and quercetin (senolytics) as neoadjuvant therapy before surgery in patients with head and neck squamous cell carcinoma. The trial assessed efficacy and safety of this combined immunotherapy-senolytic approach.
Evidence assessment pending
Read the source · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ↗