Abolere mortem

What actually changed in longevity science

Research worth understanding. News worth reading. A clearer view of living longer.

Longevity landscape

85.7years

Modeled age at death · +2.3 vs reference

Research comparison across study populations—not a personal forecast.

Click a line to see the exact studies that calculate it. Use the tags in the feed to add or remove evidence.

4 selected source groups · 50% effect transfer. Sources include different study populations; their combined effect has not been tested as a treatment package.

Starting ageUS life table

Model assumptions

Include observational evidenceReported benefit carried into modelAdditional overlapping benefitsAssumed effect duration

Effect transfer and overlap are sensitivity assumptions, not measured correction factors. Age and sex change the reference life table; they do not establish treatment eligibility. Shading shows source bounds, not a combined confidence interval.

Nonfatal harms, adherence and treatment interactions are not modeled. Model longevity-scenarios-1.

Methodology & limitations →

What matters now

Important findings, useful explanations, and setbacks worth knowing about.

All stories →

A quieter news window: showing the latest available stories with their original publication dates. Ranking reflects relevance, recency and reader interest—not proof of benefit.

Longevity news

News, research and the studies that currently shape the longevity chart—all in one stream.

Research review· Journal of drug targeting
Review of senescence-associated extracellular vesicles in skin aging and potential therapeutic approaches.
Published Sep 22, 2026Added 1moStart a discussion Share on X Senolytics
This is a review article examining the role of senescence-associated extracellular vesicles (SA-EVs) in skin aging and dysfunction. The authors describe how SA-EVs are secreted by senescent cells and carry proinflammatory cargo that promotes further senescence, impairs wound healing, and contributes to chronic wounds, diabetic ulcers, scarring, and skin aging. The review discusses potential therapeutic approaches including senolytics, senomorphics, stem cell-derived EVs, and biomaterial-assisted systems.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Journal of drug targeting ↗
Research review· Progress in neurobiology
Systematic review of sex and age differences in ischemic stroke molecular pathology and therapeutic response
Published Sep 16, 2026Added 1moStart a discussion Share on X NMN Senolytics
This systematic review examined how biological sex and aging shape molecular mechanisms in ischemic stroke, emphasizing sex-specific cell death pathways, mitochondrial dysfunction, and NAD+-sirtuin signaling. The authors describe how premenopausal females show caspase-dependent apoptosis while males exhibit PARP-1-mediated parthanatos, and how postmenopausal females lose neuroprotective advantages due to estrogen receptor changes and mitochondrial decay. The review proposes precision medicine approaches including ER-alpha modulators, NAD+ precursors, and senolytic combinations tailored to sex and reproductive stage.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Progress in neurobiology ↗
Research review· International reviews of immunology
Systematic review describes nutritional interventions, including omega-3s, as potential modulators of aging-related immune dysfunction.
Published Sep 16, 2026Added 1moStart a discussion Share on X Omega-3 fatty acids
This systematic review examines how nutritional interventions—including bioactive compounds, essential nutrients, and functional foods—might modulate immune system aging (immunosenescence) and its effects on organ function. The authors propose an "immune-organ axis" framework linking immune dysregulation to organ-specific dysfunction in conditions like neurodegeneration and chronic inflammation. The review highlights antioxidants from sources like fish oil, berries, turmeric, and algae as potentially beneficial, while noting that bioactive compounds face absorption and stability challenges.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · International reviews of immunology ↗
Research affecting the chart· PubMed
Combined lifestyle factors, all-cause mortality and cardiovascular disease
Published 2020Observational researchGeneral adult evidence
Directly changes the Combined lifestyle chart input
74 studies; 2,584,766 participants in the all-cause mortality analysis.
Study scope and limits
Adults in prospective cohorts; populations and lifestyle definitions varied.
Healthiest versus least-healthy combinations of smoking, activity, diet, weight and alcohol factors.
Observational association, with residual confounding and heterogeneous lifestyle scores. Not the effect of changing an average person’s habits. Alcohol in the score is not a recommendation to drink.
Read the study · PubMed ↗
Research review· Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Systematic review describes growth hormone receptor signaling mechanisms and Laron syndrome as a model of GH deficiency effects.
Published Sep 4, 2026Added 1moStart a discussion Share on X Growth hormone
This systematic review examines the growth hormone-IGF-I axis and its role in growth, metabolism, and tissue homeostasis. The review synthesizes knowledge of growth hormone receptor structure, signal transduction pathways (JAK2-STAT5, MAPK/ERK, PI3K-AKT-mTOR), and discusses Laron syndrome—a condition of lifelong GHR deficiency—as a human model showing that GH deficiency associates with short stature but also enhanced insulin sensitivity, preserved glucose homeostasis, increased adiposity, and low cancer incidence.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society ↗
Research review· Frontiers in immunology
Review discusses mechanisms of sarcopenia and potential therapeutic targets in the aging muscle microenvironment.
Published Sep 4, 2026Added 1moStart a discussion Share on X Exercise Senolytics
This is a review article that synthesizes evidence on the pathophysiology of sarcopenia, focusing on early changes in the muscle microenvironment rather than end-stage myofiber atrophy. The authors identify key mechanisms including dysregulated immunity, cellular senescence, satellite cell dysfunction, mitochondrial dysfunction, and impaired proteostasis. The review proposes that targeting these early alterations through exercise, nutrition, anti-inflammatory strategies, senescent cell clearance, and mitochondrial support may offer more effective therapeutic approaches than interventions addressing only late-stage muscle loss.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Frontiers in immunology ↗
Research affecting the chart· PubMed
Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality
Published 2025Observational researchGeneral adult evidence
Directly changes the Physical activity chart input
Umbrella review of meta-analyses; equivalent hazard ratio for leisure-time physical activity.
Study scope and limits
Adults in the self-reported leisure-time physical activity syntheses.
Higher versus lower self-reported leisure-time physical activity; contrasts vary across studies.
Authors classify the association as suggestive evidence. Self-report, residual confounding and overlapping reviews limit interpretation. Replaces the combined lifestyle estimate rather than stacking on it.
Read the study · PubMed ↗
Laboratory research· Frontiers in medicine
Narrative review describes necroptosis-senescence pathway in kidney fibrosis with preclinical but untranslated senolytic evidence.
Published Sep 3, 2026Added 1moStart a discussion Share on X Senolytics
This narrative review synthesized peer-reviewed literature on necroptosis, cellular senescence, and renal tubulointerstitial fibrosis, searching PubMed, Web of Science, and Embase through July 2026. The authors describe a proposed mechanistic continuum where mitochondrial DNA released from necroptotic tubular cells drives glycolytic reprogramming and a senescence-associated secretory phenotype that amplifies fibrosis. Senolytics are mentioned among existing targeted strategies showing "preclinical efficacy" but the review does not report actual senolytic trial data, effect sizes, or clinical translation success.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Frontiers in medicine ↗
Research review· Frontiers in immunology
Systematic review finds extracellular vesicles may modulate inflammation and support cartilage repair in osteoarthritis.
Published Sep 3, 2026Added 1moStart a discussion Share on X Stem cell therapy
This systematic review examined how extracellular vesicles (EVs)—small membrane-enclosed particles carrying cellular cargo—influence osteoarthritis pathology and potential treatment. The authors describe a "pathological EV cycle" in which EVs from inflammatory cells drive cartilage degradation and bone remodeling, while EVs from therapeutic cells like mesenchymal stromal cells may suppress inflammation and promote tissue repair. The review identifies engineering improvements in EV delivery and potency but notes significant limitations in translating this approach to clinical use.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Frontiers in immunology ↗
Research affecting the chart· PubMed
Efficacy and safety of more intensive lowering of LDL cholesterol
Published 2010Randomized researchCardiovascular prevention trial populations
Directly changes the Statins chart input
CTT individual participant meta-analysis of 26 trials; about 170,000 participants overall.
Study scope and limits
Participants enrolled in randomized LDL-lowering trials, with varied cardiovascular risk.
Per 1 mmol/L lower LDL cholesterol, across statin versus control and more- versus less-intensive regimens.
Mortality rate ratio is treated as a proportional hazard multiplier in this model. Trial populations and LDL changes differ; not a longevity estimate for healthy people or a prescribing recommendation.
Read the study · PubMed ↗
Animal research· Arthritis & rheumatology (Hoboken, N.J.)
SIRT6 activator MDL-800 reduced osteoarthritis severity in aging mice given monthly injections.
Published Sep 22, 2026Added 1moStart a discussion Share on X Gene therapy for ageing
Male mice aged 18 months received weekly intraperitoneal injections of MDL-800 (a SIRT6 activator) or vehicle for 6 months, then were assessed for osteoarthritis at 24 months. MDL-800-treated mice showed less cartilage damage, osteophyte formation, bone sclerosis, and meniscal ossification compared to controls. Mechanistic studies in cultured human chondrocytes showed MDL-800 suppressed catabolic signaling pathways and reduced DNA damage.
Evidence assessment pending · ANIMAL
Read the study · Arthritis & rheumatology (Hoboken, N.J.) ↗
Animal research· Frontiers in immunology
Systematic review finds platelet factor 4 modulates cognitive, immune, and hematopoietic aging through multiple signaling pathways.
Published Sep 2, 2026Added 1moStart a discussion Share on X Klotho
This systematic review examined evidence for platelet factor 4 (PF4) in age-related dysfunction across cognitive, immune, and hematopoietic systems. The authors report that PF4 engages CXCR3 and LDLR receptors to activate downstream signaling, with reported effects including reduced hippocampal neuroinflammation, enhanced synaptic plasticity, restored T-cell balance, and preserved hematopoietic stem cell function in aging. Clinical observational studies identified correlations between circulating PF4 levels and conditions including Alzheimer's disease, sarcopenia, stroke, and coronary artery disease.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Frontiers in immunology ↗
Research affecting the chart· PubMed
Cardiovascular and Kidney Outcomes and Mortality With Long-Acting GLP-1 Receptor Agonists
Published 2025Randomized researchType 2 diabetes trial populations
Directly changes the GLP-1 agonists chart input
10 randomized trials; 71,351 participants.
Study scope and limits
People with type 2 diabetes in large cardiovascular and kidney outcome trials.
Long-acting GLP-1 receptor agonist versus placebo, on top of trial background care.
Class-level synthesis in type 2 diabetes; not transferable to healthy adults, every agent, or lifelong use. Trials already include other care, so combining effects can double-count benefit.
Read the study · PubMed ↗
Observational study· Neuropsychobiology
Emotional neglect trauma associated with lower Klotho and cognitive deficits in adolescents with mood disorders: observational study.
Published Sep 21, 2026Added 1moStart a discussion Share on X Klotho
This observational study enrolled 95 adolescents with bipolar or major depressive disorder and 45 healthy controls, identifying three trauma-based subgroups through cluster analysis. Adolescents in the emotional neglect-focused trauma group had lower serum Klotho levels, higher MMP-9 levels, and worse performance on working memory and executive function tests compared to other groups and controls.
Evidence assessment pending · OBSERVATIONAL
Read the study · Neuropsychobiology ↗
Research affecting the chart· journals.plos.org
SGLT2 inhibitors in patients with chronic kidney disease with or without type 2 diabetes
Published 2023Randomized researchChronic kidney disease trial populations
Directly changes the SGLT2 inhibitors chart input
Systematic review of 14 randomized trials; all-cause mortality is a secondary endpoint.
Study scope and limits
People with chronic kidney disease, with or without type 2 diabetes.
SGLT2 inhibitor plus standard therapy versus placebo or standard therapy.
The 14 trials cover the review as a whole, not necessarily this endpoint. Kidney disease populations differ from the reference life table. Background treatment overlaps with other selections.
Read the study · journals.plos.org ↗

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Epigenetic clocks →Metformin →Senolytics →Smoking cessation →Exercise →SGLT2 inhibitors →Klotho →Air quality →