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- Trial registry · no verified findings· Steadman Philippon Research Institute
The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Steadman Philippon Research Institute ↗ - Trial registry · no verified findings· AgelessRx
Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study (PEARL): A Prospective, Double-Blind, Placebo-Controlled Trial for Rapamycin in Healthy Individuals Assessing Safety and Efficacy in Reducing Aging Effects
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · AgelessRx ↗ - Trial registry · no verified findings· University of New Mexico
A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · University of New Mexico ↗ - Trial registry · no verified findings· Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
RCT of immunotherapy plus senolytics versus control before head and neck cancer surgery
A Phase II randomised controlled trial evaluated tislelizumab (anti-PD-1 antibody) combined with dasatinib and quercetin (senolytics) as neoadjuvant therapy before surgery in patients with head and neck squamous cell carcinoma. The trial assessed efficacy and safety of this combined immunotherapy-senolytic approach.
Evidence assessment pending · OTHER
Read the source · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ↗ - Trial registry · no verified findings· James L. Kirkland, MD, PhD
COVFIS-HOME: A Phase 2 Placebo-Controlled Pilot Study in COVID-19 of Fisetin to Alleviate Dysfunction and Decrease Complications in At-Risk Outpatients
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · James L. Kirkland, MD, PhD ↗ - Trial registry · no verified findings· Assiut University
Evaluation of the Efficacy of Natural Senolytic Agents and NLRP3 Inhibitors in Treatment of Osteoarthritis: Randomized, Double Blinded ,Placebo Controlled Trial
Trial registry update: SUSPENDED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Assiut University ↗ - Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio
An Innovative Proof-of-concept Approach to Identify Age-modulating Drugs Capable of Reversing Inflammation and Re-setting the Epigenetic Clock (Topical-RAPA)
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · The University of Texas Health Science Center at San Antonio ↗ - Trial registry · no verified findings· AgelessRx
The Bioavailability of Compounded and Generic Rapamycin in Normative Aging Individuals: A Retrospective Study and Review With Clinical Implications
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · OBSERVATIONAL
Read the source · AgelessRx ↗ - Trial registry · no verified findings· University of California, San Francisco
METforMIN: Metformin Administration for the Minimization of Geographic Atrophy Progression in Patients With Age-related Macular Degeneration
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · University of California, San Francisco ↗ - Trial registry · no verified findings· Mayo Clinic
(MATE) Metformin and Aging Trial in the Elderly: A Pilot and Feasibility Study
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Austin V Stone
Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)
Trial registry update: WITHDRAWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Austin V Stone ↗ - Trial registry · no verified findings· LuZhe Sun
Aging Mammary Stem Cells and Breast Cancer Prevention
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
Evidence assessment pending · OTHER
Read the source · LuZhe Sun ↗ - Trial registry · no verified findings· Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Randomized Controlled Trial of Metformin and Dietary Restriction to Prevent Age-related Morbid Events in People With Metabolic Syndrome
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano ↗ - Trial registry · no verified findings· Albert Einstein College of Medicine
Metformin in Longevity Study (MILES).
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Albert Einstein College of Medicine ↗ - Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio
Pilot Study to Investigate the Safety and Feasibility of Senolytic Therapy to Modulate Progression of Alzheimer's Disease (SToMP-AD)
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · CASE REPORT
Read the source · The University of Texas Health Science Center at San Antonio ↗ - Trial registry · no verified findings· UConn Health
Vaccination Efficacy With Metformin in Older Adults: A Pilot Study
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · UConn Health ↗ - Trial registry · no verified findings· Wake Forest University Health Sciences
Senolytic drugs dasatinib plus quercetin reduced pro-inflammatory cells in small open-label IPF pilot study.
Open-label pilot study in patients with idiopathic pulmonary fibrosis examining intermittent oral dosing of dasatinib plus quercetin over 3 weeks. The intervention aimed to reduce pro-inflammatory cells and cellular senescence markers. The study assessed safety, tolerability, and effects on inflammatory biomarkers, with hypothesized preservation of functional outcomes.
Evidence assessment pending · RCT
Read the source · Wake Forest University Health Sciences ↗ - Trial registry · no verified findings· VA Office of Research and Development
Metformin and Muscle in Insulin-resistant Older Veterans
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · VA Office of Research and Development ↗ - Trial registry · no verified findings· Philip Kern
Novel Actions of Metformin to Augment Resistance Training Adaptations in Older Adults
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Philip Kern ↗ - Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio
Effect of Mammalian Target of Rapamycin Inhibition and Other Metabolism Modulating Interventions on the Elderly: Immune, Cognitive, and Functional Consequences
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · The University of Texas Health Science Center at San Antonio ↗ - Trial registry · no verified findings· TruDiagnostic
The Safety and Effectivness of Quercetin and Dasatinib on the Epigenetic Aging Rates in Healthy Individuals
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending · OBSERVATIONAL
Read the source · TruDiagnostic ↗ - Trial registry · no verified findings· National Eye Institute (NEI)
Pilot Study of the Evaluation of Intravitreal Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated With Age-Related Macular Degeneration
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · OTHER
Read the source · National Eye Institute (NEI) ↗ - Trial registry · no verified findings· Maturi, Raj K., M.D., P.C.
Sirolimus Versus AntiVEGF for Wet AMD
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Maturi, Raj K., M.D., P.C. ↗ - Trial registry · no verified findings· National Eye Institute (NEI)
Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral Geographic Atrophy Associated With Age-Related Macular Degeneration
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · OTHER
Read the source · National Eye Institute (NEI) ↗ - Trial registry · no verified findings· Mayo Clinic
Role of Exercise and Low-Dose Rapamycin on Age-Associated Impairments in Older Adults With Coronary Artery Disease: Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· National Eye Institute (NEI)
Treatment of Choroidal Subretinal Neovascularization With Agents Directed Against the Immune Response
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · National Eye Institute (NEI) ↗ - Trial registry · no verified findings· Indonesia University
Randomized-Controlled Trial of Metformin to Prevent Frailty in Pre-frail Elderly
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Indonesia University ↗ - Trial registry · no verified findings· Xiang Guang-da
Chronic Metformin Treatment Induces a Dietary Restriction-like State in Overweight Human
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Xiang Guang-da ↗ - Trial registry · no verified findings· National Eye Institute (NEI)
Multi-Center, Randomized, Single Masked Phase 2 Study of Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration
Trial registry update: TERMINATED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · National Eye Institute (NEI) ↗ - Trial registry · no verified findings· Guy's and St Thomas' NHS Foundation Trust
METformin And Longevity (METAL): A Window of Opportunity Study Investigating Biological Effects of Metformin in Localised Prostate Cancer
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Guy's and St Thomas' NHS Foundation Trust ↗