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  12. Research review· Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

    Systematic review describes growth hormone receptor signaling mechanisms and Laron syndrome as a model of GH deficiency effects.

    Published Sep 4, 2026Added 1moStart a discussionShare on XGrowth hormone

    This systematic review examines the growth hormone-IGF-I axis and its role in growth, metabolism, and tissue homeostasis. The review synthesizes knowledge of growth hormone receptor structure, signal transduction pathways (JAK2-STAT5, MAPK/ERK, PI3K-AKT-mTOR), and discusses Laron syndrome—a condition of lifelong GHR deficiency—as a human model showing that GH deficiency associates with short stature but also enhanced insulin sensitivity, preserved glucose homeostasis, increased adiposity, and low cancer incidence.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society ↗
  13. Research review· Frontiers in immunology

    Review discusses mechanisms of sarcopenia and potential therapeutic targets in the aging muscle microenvironment.

    Published Sep 4, 2026Added 1moStart a discussionShare on XExerciseSenolytics

    This is a review article that synthesizes evidence on the pathophysiology of sarcopenia, focusing on early changes in the muscle microenvironment rather than end-stage myofiber atrophy. The authors identify key mechanisms including dysregulated immunity, cellular senescence, satellite cell dysfunction, mitochondrial dysfunction, and impaired proteostasis. The review proposes that targeting these early alterations through exercise, nutrition, anti-inflammatory strategies, senescent cell clearance, and mitochondrial support may offer more effective therapeutic approaches than interventions addressing only late-stage muscle loss.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Frontiers in immunology ↗
  15. Laboratory research· Frontiers in medicine

    Narrative review describes necroptosis-senescence pathway in kidney fibrosis with preclinical but untranslated senolytic evidence.

    Published Sep 3, 2026Added 1moStart a discussionShare on XSenolytics

    This narrative review synthesized peer-reviewed literature on necroptosis, cellular senescence, and renal tubulointerstitial fibrosis, searching PubMed, Web of Science, and Embase through July 2026. The authors describe a proposed mechanistic continuum where mitochondrial DNA released from necroptotic tubular cells drives glycolytic reprogramming and a senescence-associated secretory phenotype that amplifies fibrosis. Senolytics are mentioned among existing targeted strategies showing "preclinical efficacy" but the review does not report actual senolytic trial data, effect sizes, or clinical translation success.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Frontiers in medicine ↗
  16. Research review· Frontiers in immunology

    Systematic review finds extracellular vesicles may modulate inflammation and support cartilage repair in osteoarthritis.

    Published Sep 3, 2026Added 1moStart a discussionShare on XStem cell therapy

    This systematic review examined how extracellular vesicles (EVs)—small membrane-enclosed particles carrying cellular cargo—influence osteoarthritis pathology and potential treatment. The authors describe a "pathological EV cycle" in which EVs from inflammatory cells drive cartilage degradation and bone remodeling, while EVs from therapeutic cells like mesenchymal stromal cells may suppress inflammation and promote tissue repair. The review identifies engineering improvements in EV delivery and potency but notes significant limitations in translating this approach to clinical use.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Frontiers in immunology ↗
  17. Animal research· Arthritis & rheumatology (Hoboken, N.J.)

    SIRT6 activator MDL-800 reduced osteoarthritis severity in aging mice given monthly injections.

    Published Sep 22, 2026Added 1moStart a discussionShare on XGene therapy for ageing

    Male mice aged 18 months received weekly intraperitoneal injections of MDL-800 (a SIRT6 activator) or vehicle for 6 months, then were assessed for osteoarthritis at 24 months. MDL-800-treated mice showed less cartilage damage, osteophyte formation, bone sclerosis, and meniscal ossification compared to controls. Mechanistic studies in cultured human chondrocytes showed MDL-800 suppressed catabolic signaling pathways and reduced DNA damage.

    Evidence assessment pending · ANIMAL

    Read the study · Arthritis & rheumatology (Hoboken, N.J.) ↗
  18. Animal research· Frontiers in immunology

    Systematic review finds platelet factor 4 modulates cognitive, immune, and hematopoietic aging through multiple signaling pathways.

    Published Sep 2, 2026Added 1moStart a discussionShare on XKlotho

    This systematic review examined evidence for platelet factor 4 (PF4) in age-related dysfunction across cognitive, immune, and hematopoietic systems. The authors report that PF4 engages CXCR3 and LDLR receptors to activate downstream signaling, with reported effects including reduced hippocampal neuroinflammation, enhanced synaptic plasticity, restored T-cell balance, and preserved hematopoietic stem cell function in aging. Clinical observational studies identified correlations between circulating PF4 levels and conditions including Alzheimer's disease, sarcopenia, stroke, and coronary artery disease.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Frontiers in immunology ↗
  19. Observational study· Neuropsychobiology

    Emotional neglect trauma associated with lower Klotho and cognitive deficits in adolescents with mood disorders: observational study.

    Published Sep 21, 2026Added 1moStart a discussionShare on XKlotho

    This observational study enrolled 95 adolescents with bipolar or major depressive disorder and 45 healthy controls, identifying three trauma-based subgroups through cluster analysis. Adolescents in the emotional neglect-focused trauma group had lower serum Klotho levels, higher MMP-9 levels, and worse performance on working memory and executive function tests compared to other groups and controls.

    Evidence assessment pending · OBSERVATIONAL

    Read the study · Neuropsychobiology ↗
  21. Research review· Journal of cellular and molecular medicine

    Systematic review examines molecular mechanisms of skin aging and therapeutic approaches including stem cell therapy.

    Published Sep 1, 2026Added 1moStart a discussionShare on XStem cell therapy

    This is a narrative review that describes the phenotypes and mechanisms of skin aging, including reduced regenerative capacity, chronic inflammation, impaired barrier function, oxidative stress, DNA damage, and epigenetic alterations. The authors evaluate recent research on pharmacological interventions and stem cell therapy for mitigating skin aging, along with delivery systems for natural compounds and the potential of AI in drug discovery. No specific efficacy data or effect sizes for stem cell therapy are reported.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Journal of cellular and molecular medicine ↗
  22. Laboratory research· International journal of food science

    Curcumin reduced oxidative stress and promoted neural differentiation in cultured stem cells in vitro.

    Published Sep 20, 2026Added 1moStart a discussionShare on XStem cell therapy

    This in vitro study tested curcumin's effects on C17.2 neural stem cells exposed to oxidative stress. Curcumin-treated cells showed improved survival, reduced reactive oxygen species levels, enhanced antioxidant markers, and promoted differentiation into neurons and astrocytes, with apparent involvement of the Wnt3α/β-catenin/Cyclin D1 signaling pathway.

    Evidence assessment pending · IN VITRO

    Read the study · International journal of food science ↗
  24. Observational study· Medicine

    Higher diet quality associated with lower odds of accelerated biological aging in observational study.

    Published Sep 18, 2026Added 1moStart a discussionShare on XMediterranean diet

    This cross-sectional analysis of 12,511 U.S. adults from NHANES 2005-2010 examined whether diet quality, measured by the Healthy Eating Index-2015 (HEI-2015), was associated with phenotypic age acceleration derived from 9 clinical biomarkers. Each 1-point increase in HEI-2015 was associated with lower odds of accelerated aging (OR = 0.98, 95% CI: 0.97-0.98). Mediation analysis found that approximately 29% of this association was mediated through body shape indices, particularly waist-to-height ratio and Body Roundness Index.

    Evidence assessment pending · OBSERVATIONAL

    Read the study · Medicine ↗
  25. Research paper· Neuron

    Partial cellular reprogramming via miR-10a-5p-γCaMKII axis linked to cognitive decline in female midlife in preclinical models.

    Published Sep 18, 2026Added 1moStart a discussionShare on XPartial cellular reprogramming

    This preclinical study investigated senescence-associated features in middle-aged female mice and human tissues, identifying an epigenetic upregulation of RBMX that increases splenic miR-10a-5p levels. The researchers found that miR-10a-5p can cross from the periphery to the brain, where it represses γCaMKII, influencing mitochondrial function, cellular senescence, and memory performance. In neurons from Alzheimer's disease patients and in model mice, inhibition of miR-10a-5p attenuated disease-associated phenotypes.

    Evidence assessment pending · PRECLINICAL

    Read the study · Neuron ↗
  26. Observational study· British dental journal

    Metformin and azithromycin lower acquisition costs than amoxicillin-metronidazole for periodontitis: cost analysis

    Published Sep 18, 2026Added 1moStart a discussionShare on XMetformin

    This observational cost comparison analysed 445 antibiotic prescriptions for periodontitis at a UK dental hospital between 2021-2024. Azithromycin reduced acquisition costs by 55% compared to guideline-recommended amoxicillin plus metronidazole (£2.81 per course). Non-antimicrobial adjuncts including metformin 500 mg achieved up to 91% cost reductions depending on treatment duration.

    Evidence assessment pending · OBSERVATIONAL

    Read the study · British dental journal ↗
  28. Research paper· Molecular genetics and genomics : MGG

    USP22 protein reduces senescence in bone marrow stem cells exposed to oxidative stress in vitro

    Published Sep 17, 2026Added 1moStart a discussionShare on XStem cell therapy

    This in vitro study examined how USP22 affects bone marrow mesenchymal stem cells (BMSCs) exposed to hydrogen peroxide to simulate oxidative stress. Researchers found that USP22 stabilized the SPI1 protein through deubiquitination, which increased NAMPT expression and NAD+ levels, reducing cellular senescence markers and preserving the cells' capacity to differentiate into bone tissue.

    Evidence assessment pending · IN VITRO

    Read the study · Molecular genetics and genomics : MGG ↗
  29. Laboratory research· npj aging

    Cell imaging and RNA sequencing characterize senolytic effects in cultured senescent cells.

    Published Sep 17, 2026Added 1moStart a discussionShare on XSenolytics

    This in vitro study used high-content cell imaging and transcriptomics to characterize senescence mechanisms and distinguish between replicative and chemically induced senescence, as well as differentiate senescence from quiescence. The authors also characterized how senolytics respond in this system.

    Evidence assessment pending · IN VITRO

    Read the study · npj aging ↗
  30. Research review· Nutrients

    Systematic review identifies dysbiosis mechanisms but no clinical evidence for dietary interventions in cancer survivor cognition.

    Published Aug 25, 2026Added 1moStart a discussionShare on XMediterranean diet

    This systematized narrative review synthesized evidence from in vivo models and observational studies on how cancer therapies damage the gut microbiome and how dietary patterns may influence long-term neurocognitive outcomes in adolescent and young adult survivors of childhood cancer. The authors propose that chemotherapy-induced dysbiosis leads to reduced short-chain fatty acid production and intestinal barrier dysfunction, driving neuroinflammation and cognitive deficits, and that anti-inflammatory diets such as MIND and postbiotics show "measurable restorative potential." However, the review found no completed randomized controlled trials testing these interventions in cancer survivors.

    Evidence assessment pending · SYSTEMATIC REVIEW

    Read the study · Nutrients ↗