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Dates show original publication, separately from when we added the story. Clinical trials lists registry activity separately. Check collection coverage.

  1. Trial registry · no verified findings· Cedars-Sinai Medical Center

    A Nutritional and Pharmacological Intervention for Body, Brain, and Longevity Effects (NIBBLE) - A Randomized Open-label Intervention of the Fasting-mimicking Diet (FMD) and Rapamycin (NIBBLE)

    Published Sep 16, 2026Added 1moStart a discussionShare on XRapamycinIntermittent fasting

    Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending · RCT

    Read the source · Cedars-Sinai Medical Center ↗
  3. Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio

    Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly: Immune, Cognitive, and Functional Consequences ((Substudy E - RAPA cMRI With LGE)

    Published Sep 23, 2026Added 1moStart a discussionShare on XRapamycin

    Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending · OTHER

    Read the source · The University of Texas Health Science Center at San Antonio ↗
  4. Trial registry · no verified findings· Icahn School of Medicine at Mount Sinai

    A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging

    Published Aug 27, 2026Added 1moStart a discussionShare on XExerciseSpermidine

    Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending · RCT

    Read the source · Icahn School of Medicine at Mount Sinai ↗
  7. Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio

    RESTOR [Rapamycin and Everolimus Study Towards Older Rejuvenation]: An Exploratory PK/PD Study of mTOR Inhibition in Older Human Subjects

    Published Jun 1, 2026Added 1moStart a discussionShare on XRapamycin

    Trial registry update: RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending · RCT

    Read the source · The University of Texas Health Science Center at San Antonio ↗
  15. Trial registry · no verified findings· AgelessRx

    Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study (PEARL): A Prospective, Double-Blind, Placebo-Controlled Trial for Rapamycin in Healthy Individuals Assessing Safety and Efficacy in Reducing Aging Effects

    Published Jan 24, 2024Added 1moStart a discussionShare on XRapamycin

    Trial registry update: COMPLETED. No results reported in the supplied registry record.

    Evidence assessment pending · RCT

    Read the source · AgelessRx ↗
  16. Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio

    An Innovative Proof-of-concept Approach to Identify Age-modulating Drugs Capable of Reversing Inflammation and Re-setting the Epigenetic Clock (Topical-RAPA)

    Published Jul 19, 2023Added 1moStart a discussionShare on XRapamycin

    Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.

    Evidence assessment pending · RCT

    Read the source · The University of Texas Health Science Center at San Antonio ↗
  19. Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio

    Effect of Mammalian Target of Rapamycin Inhibition and Other Metabolism Modulating Interventions on the Elderly: Immune, Cognitive, and Functional Consequences

    Published Dec 4, 2018Added 1moStart a discussionShare on XRapamycin

    Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.

    Evidence assessment pending · RCT

    Read the source · The University of Texas Health Science Center at San Antonio ↗
  26. Trial registry · no verified findings· Santen Inc.

    A Phase 1/2, Randomized Clinical Study to Assess the Safety and Efficacy of Sirolimus in Patients With Newly Diagnosed, Treatment-Naive Sub-Foveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

    Published Jan 10, 2013Added 1moStart a discussionShare on XRapamycin

    Trial registry update: TERMINATED. No results reported in the supplied registry record.

    Evidence assessment pending · RCT

    Read the source · Santen Inc. ↗
  27. Trial registry · no verified findings· Santen Inc.

    A Phase 2, Randomized, Masked, Controlled Clinical Study to Assess the Safety and Efficacy of Lucentis® Plus Sirolimus Versus Lucentis® Plus Placebo in Patients With Sub-Foveal Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

    Published Jan 10, 2013Added 1moStart a discussionShare on XRapamycin

    Trial registry update: TERMINATED. No results reported in the supplied registry record.

    Evidence assessment pending · RCT

    Read the source · Santen Inc. ↗
  28. Trial registry · no verified findings· Novartis Pharmaceuticals

    RCT of oral everolimus alone or with lucentis for neovascular age-related macular degeneration; results not reported

    Published Aug 19, 2011Added 1moStart a discussionShare on XRapamycin

    A randomised, double-masked, parallel group study designed to assess the safety and efficacy of oral everolimus (an mTOR inhibitor in the rapamycin class) alone or combined with lucentis in patients with neovascular age-related macular degeneration. No efficacy or safety results were reported in the material provided.

    Evidence assessment pending · RCT

    Read the source · Novartis Pharmaceuticals ↗