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Dates show original publication, separately from when we added the story. Clinical trials lists registry activity separately. Check collection coverage.

  1. Trial registry · no verified findings· Genentech, Inc.

    Phase IIa trial evaluates safety and feasibility of subretinal OpRegen stem cell delivery in geographic atrophy.

    Published Sep 15, 2026Added 1moStart a discussionShare on XStem cell therapy

    This Phase IIa open-label single-arm study assessed the surgical feasibility and safety of subretinal delivery of OpRegen (a stem cell therapy) in patients with geographic atrophy secondary to age-related macular degeneration. The trial also evaluated preliminary activity of the intervention. A substudy explored incorporation of advanced retinal imaging as an assessment tool.

    Evidence assessment pending

    Read the source · Genentech, Inc. ↗
  4. Trial registry · no verified findings· State University of New York at Buffalo

    Community recreation program with art and exergaming tested in older adults for cognitive and physical effects

    Published Aug 19, 2026Added 1moStart a discussionShare on XExercise

    Researchers delivered a 24-week community-based program combining group artmaking and dual-task exergaming to community-dwelling older adults through a local YMCA. The study measured changes in cognitive function and physical functioning in response to the intervention.

    Evidence assessment pending

    Read the source · State University of New York at Buffalo ↗
  5. Trial registry · no verified findings· Indiana University

    Foot-strengthening interventions tested in randomized trial for balance and gait in adults 45-85.

    Published Aug 19, 2026Added 1moStart a discussionShare on XResistance training

    This randomized controlled trial compared four arms—minimalist footwear, a foot exercise program, a foot-strengthening device (ToePro), and no intervention—in middle-aged and older adults (ages 45-85) over 8 weeks. Participants completed foot strength, balance, gait, and physical function testing at baseline and post-intervention, with interventions performed five days per week. The abstract does not report specific effect sizes, statistical outcomes, or whether any intervention produced meaningful changes.

    Evidence assessment pending

    Read the source · Indiana University ↗
  6. Trial registry · no verified findings· University of Illinois at Chicago

    Randomised trial of cognitive-motor training game on cognition and physical outcomes in older adults with mild cognitive impairment

    Published Aug 18, 2026Added 1moStart a discussionShare on XExercise

    This randomised controlled trial investigated a novel computer vision-based cognitive-motor training program (CogXergaming) designed for older adults with mild cognitive impairment (MCI). The intervention aimed to improve cognitive-motor function, physical activity, falls efficacy, and quality of life compared to control. The abstract does not report the results of the study, sample size, or effect sizes.

    Evidence assessment pending

    Read the source · University of Illinois at Chicago ↗
  12. Trial registry · no verified findings· Huazhong University of Science and Technology

    RCT evaluates urolithin A and fisetin on sleep quality and aging biomarkers in middle-aged and older adults

    Published Aug 10, 2026Added 1moStart a discussionShare on XSleep

    This randomized controlled trial compared four groups—placebo, 500 mg urolithin A, 500 mg fisetin, and a 300 mg urolithin A + 200 mg fisetin combination—over 12 weeks in middle-aged and older adults. Participants took daily capsules and underwent assessments at baseline, week 4, and week 12, including sleep quality measures (PSQI, actigraphy, polysomnography), aging biomarkers (DNA methylation, inflammatory cytokines), and gut microbiome analysis. The abstract describes the study design and planned assessments but does not report any results or findings.

    Evidence assessment pending

    Read the source · Huazhong University of Science and Technology ↗
  25. Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio

    RESTOR [Rapamycin and Everolimus Study Towards Older Rejuvenation]: An Exploratory PK/PD Study of mTOR Inhibition in Older Human Subjects

    Published Jun 1, 2026Added 1moStart a discussionShare on XRapamycin

    Trial registry update: RECRUITING. No results reported in the supplied registry record.

    Evidence assessment pending

    Read the source · The University of Texas Health Science Center at San Antonio ↗
  30. Trial registry · no verified findings· Mayo Clinic

    Fisetin reduced inflammatory markers in elderly women with gait disturbance in a phase 2 RCT

    Published May 11, 2026Added 1moStart a discussionShare on XSenolytics

    AFFIRM was a phase 2 randomized placebo-controlled trial testing fisetin (a senolytic) in older women with gait disturbance. The study aimed to evaluate effects on insulin resistance markers, inflammation, bone resorption, and physical dysfunction. Specific results were not reported in the provided abstract.

    Evidence assessment pending

    Read the source · Mayo Clinic ↗