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- Trial registry · no verified findings· Northwestern University
Fisetin to Reduce Senescence and Mobility Impairment in Peripheral Artery Disease: the FIRST Pilot Randomized Trial
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Northwestern University ↗ - Trial registry · no verified findings· Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Dasatinib and Quercetin, a Combination of Senolytics to Treat Fibrotic Non-alcoholic Fatty Liver Disease - the TRUTH Study
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) ↗ - Trial registry · no verified findings· Odense University Hospital
Targeting mTOR With Everolimus and/or Physical Training for Preventing Postmenopausal Bone Loss and Accelerated Skeletal Aging: The RapaLoad Study
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Odense University Hospital ↗ - Trial registry · no verified findings· Odense University Hospital
Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Odense University Hospital ↗ - Trial registry · no verified findings· Washington University School of Medicine
Phase II Clinical Trial to Evaluate the Safety and Feasibility of Senolytic Therapy in Alzheimer's Disease
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Washington University School of Medicine ↗ - Trial registry · no verified findings· Cedars-Sinai Medical Center
Single Nuclei RNA-sequencing to Map Adipose Cellular Populations and Senescent Cells in Older Subjects
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Cedars-Sinai Medical Center ↗ - Trial registry · no verified findings· AgelessRx
A Pilot Randomized Controlled Study of Combinatorial Gerotherapeutics for Healthspan Improvement
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · AgelessRx ↗ - Trial registry · no verified findings· Mayo Clinic
Proposed RCT of fisetin on stem cell function and kidney outcomes in advanced chronic kidney disease
This is a proposed study protocol, not a completed trial. The researchers planned to examine whether fisetin would improve adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, inflammation markers, and physical function in individuals with advanced chronic kidney disease. No results are reported because the study has not been conducted.
Evidence assessment pending · RCT
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Washington University School of Medicine
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · OTHER
Read the source · Washington University School of Medicine ↗ - Trial registry · no verified findings· Columbia University
Effect of Rapamycin in Ovarian Aging
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Columbia University ↗ - Trial registry · no verified findings· Diabetes Foundation, India
The Effect of Metformin Treatment on Surrogate Markers of Ageing (Leukocyte Telomere Length and Telomerase Activity), Longevity Gene Expression (Sirtuin 1, p66Shc, p53, Andmammalian Target of Rapamycin ), in North Indian Individuals With the Prediabetes: A Randomized Control Trial
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Diabetes Foundation, India ↗ - Trial registry · no verified findings· Second Affiliated Hospital, Zhejiang University, School of Medicine
Assessing the Role of GLP-1 Receptor Agonist Semaglutide and Dual GLP-I/GIP Receptor Agonist Tirzepatide in Delaying Genetic Aging in Adult Obese Patients Using the iWatchAge Technology
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Second Affiliated Hospital, Zhejiang University, School of Medicine ↗ - Trial registry · no verified findings· Ohio State University
Senolytics to Improve Physical and Cognitive Function in Older Adults With Multiple Sclerosis
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Ohio State University ↗ - Trial registry · no verified findings· University of Utah
Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · University of Utah ↗ - Trial registry · no verified findings· State University of New York at Buffalo
Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS): Randomized, Placebo-controlled Pilot Study.
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · State University of New York at Buffalo ↗ - Trial registry · no verified findings· Mayo Clinic
COVID-FISETIN: A Phase 2 Placebo-Controlled Pilot Study in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Hospitalized Adults
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· Mayo Clinic
COVID-FIS: A Phase 2 Placebo-Controlled Pilot Study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Mayo Clinic ↗ - Trial registry · no verified findings· AgelessRx
Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation: A Randomized, Controlled Trial
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · AgelessRx ↗ - Trial registry · no verified findings· Fundación Instituto de Investigación Sanitaria de Navarra
Exploring the Anti-ageing Effects of Metformin in COPD
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Fundación Instituto de Investigación Sanitaria de Navarra ↗ - Trial registry · no verified findings· Austin V Stone
Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair
Trial registry update: WITHDRAWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Austin V Stone ↗ - Trial registry · no verified findings· University of Nottingham
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle.
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · University of Nottingham ↗ - Trial registry · no verified findings· Xuanwu Hospital, Beijing
A Phase II Exploratory Clinical Study Investigating the Geroprotective Effect of Metformin in Middle-aged and Elderly People
Trial registry update: RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Xuanwu Hospital, Beijing ↗ - Trial registry · no verified findings· Steadman Philippon Research Institute
Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Steadman Philippon Research Institute ↗ - Trial registry · no verified findings· The University of Texas Health Science Center at San Antonio
Metformin and Vaccine Response in Older Adults
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · The University of Texas Health Science Center at San Antonio ↗ - Trial registry · no verified findings· Sundeep Khosla, M.D.
Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans: A Phase 2, Single-Center, 20-week, Open-Label, Randomized Controlled Trial.
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Sundeep Khosla, M.D. ↗ - Trial registry · no verified findings· Qualia Life Sciences
An Open-Label Pilot Study of Qualia Senolytic Supplementation for the Attenuation of Systemic Inflammatory Cytokines
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Evidence assessment pending · OTHER
Read the source · Qualia Life Sciences ↗ - Trial registry · no verified findings· Matthew Neal MD
Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Optimizing Surgical Outcomes at UPMC
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
Evidence assessment pending · RCT
Read the source · Matthew Neal MD ↗ - Trial registry · no verified findings· Lewis Lipsitz
Senolytics To Alleviate Mobility Issues and Neurological Impairment in Aging
Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.
Evidence assessment pending · OTHER
Read the source · Lewis Lipsitz ↗ - Trial registry · no verified findings· Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Klotho levels associated with bone density in women with systemic sclerosis: observational cross-sectional study
This observational cross-sectional study examined whether klotho and related cytokines are associated with bone mineral density and osteoimmunological markers in female patients aged 45-65 with systemic sclerosis, compared to age and gender-matched healthy controls. The study investigates whether these factors relate to the microvascular damage and fibrosis characteristic of systemic sclerosis. No effect sizes, sample sizes, or specific findings are reported in the abstract.
Evidence assessment pending · OBSERVATIONAL
Read the source · Fondazione Policlinico Universitario Agostino Gemelli IRCCS ↗ - Trial registry · no verified findings· Steadman Philippon Research Institute
The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
Evidence assessment pending · RCT
Read the source · Steadman Philippon Research Institute ↗